Pelargonium sidoides DC. vs. Pelargonium reniforme (Andrews) Curtis – active constituents and medicinal effects

Czech version

Authors: Zdeňka Navrátilová
Authors‘ workplace: Přírodovědecká fakulta UK, katedra botaniky, Praha
Published in: Čes. slov. Farm., 2026; 75, 35-41
Category: Medical Plants and Nutraceutics
doi: https://doi.org/10.36290/csf.2026.007

Overview

Pelargonium sidoides and Pelargonium reniforme are two closely related species of geraniums growing in Southern Africa. The species belong to the section Reniformia and are morphologically quite similar and often confused. Both species are used for medicinal purposes, but differ in the representation of the compounds and pharmacological effects. The article summarizes information about their composition and medicinal effects and compare it.

Keywords:

Bronchitis – cold – Pelargonium sidoides – Pelargonium reniforme – Pelargonii radix – EPs 7630 – Umckaloabo

Sources

1. Kolodziej H. Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo®. Phytomedicine 2007;14 : 9-17.

2. Kolodziej H. Pelargonium reniforme and Pelargonium sidoides: their botany, chemistry and medicinal use. In: Lis-Balchin M (ed.). Geranium and Pelargonium. Medicinal and Aromatic Plants –⁠ Industrial Profiles. London, New York: Taylor & Francis; 2002. pp. 262-90.

3. EMA (European Medicines Agency), Committee on Herbal Medicinal Products. Assessment report on Pelargonium sidoides DC and/or Pelargonium reniforme Curt., radix. EMA/HMPC/444251/2015.

4. Bladt S, Wagner H. From the Zulu medicine to the European phytomedicine Umckaloabo. Phytomedicine. 2007;14(Suppl 6):2-4.

5. Brendler T, van Wyk BE. A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae). J Ethnopharmacol. 2008;119(3):420-33.

6. Navrátilová Z. Léčivý muškát Pelargonium sidoides. Prakt lékáren. 2012;8(6):290-2.

7. Kolektiv autorů. Český lékopis 2023. Praha: Grada; 2023. pp. 5666-8.

8. Dreyer LL, Marais EM. Section Reniformia, a new section in the genus Pelargonium (Geraniaceae). S Afr J Bot 2000;66(1):44-51.

9. Eggli U, Nyffeler R (eds.). Dicotyledons: Rosids. Illustrated Handbook of Succulent Plants. 2nd ed. Switzerland AG: Springer Nature; 2023.

10. Jahodář L. Farmaceuticky významné semenné rostliny. Praha: Karolinum; 2022.

11. Maree JE, Viljoen AM. Phytochemical distinction between Pelargonium sidoides and Pelargonium reniforme –⁠ A quality control perspective. South Afr J Bot. 2012;82 : 83-91.

12. Viljoen AM, Zhao J, Sandasi M, et al. Phytochemical distinction between Pelargonium sidoides (‘‘Umckaloabo’’) and P. reniforme through 1H-NMR and UHPLC–MS metabolomic profiling. Metabolomics. 2015;11 : 594-602.

13. Kayser O, Kolodziej H. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med. 1997;63(6):508-10.

14. Kolodziej H, Kiderlen AF. In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparation EPs® 7630. Phytomedicine. 2007;14 : 18-26.

15. Mativandlela SPN, Lall N, Meyer JJM. Antibacterial, antifungal and antitubercular activity of (the roots of) Pelargonium reniforme (CURT) and Pelargonium sidoides (DC) (Geraniaceae) root extracts. South Afr J Bot. 2006;72 : 232-7.

16. Papies J, Emanuel J, Heinemann N. Antiviral and immunomodulatory effects of Pelargonium sidoides DC. root extract EPs® 7630 in SARS-CoV-2-infected human lung cells. Front Pharmacol. 2021;12 : 757666.

17. Emanuel J, Papies J, Galander C. In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/ AY.117 and Omicron BA.2. Front Pharmacol. 2023;14 : 1214351.

18. Cinatl J Jr, Wass MN, Michaelis M. Multiple mechanisms enable broad-spectrum activity of the Pelargonium sidoides root extract EPs 7630 against acute respiratory tract infections. Front Pharmacol. 2024;15 : 1455870.

19. Agbabiaka TB, Gao R, Ernst E. Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. Phytomedicine. 2008;15(5):378-85.

20. Careddu D, Pettenazzu A. Pelargonium sidoides extract EPs 7630: a review of its clinical efficacy and safety for treating acute respiratory tract infections in children. Int J Gen Med. 2018;11 : 91-8.

21. Bachert C, Schapoval A, Funk P. Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPs 7630: a randomized, double-blind, placebo-controlled trial. Rhinology. 2009;47(1):51-8.

22. Gökçe Ş, Dörtkardeşler BE, Yurtseven A, et al. Effectiveness of Pelargonium sidoides in pediatric patients diagnosed with uncomplicated upper respiratory tract infection: a single-blind, randomized, placebo-controlled study. Eur J Pediatr. 2021;180(9):3019-28.

23. Willcox M, Simpson C, Wilding S, et al. Pelargonium sidoides root extract for the treatment of acute cough due to lower respiratory tract infection in adults: a feasibility double-blind, placebo-controlled randomised trial. BMC Complement Med Ther. 2021;21(1):48.

24. Tahan F, Yaman M. Can the Pelargonium sidoides root extract EPs 7630 prevent asthma attacks during viral infections of the upper respiratory tract in children? Phytomedicine. 2013;20(2):148-50.

25. Matthys H, Funk P. Pelargonium sidoides preparation EPs 7630 in COPD: health-related quality-of-life and other patient-reported outcomes in adults receiving add-on therapy. Curr Med Res Opin. 2018;34(7):1245-51.

26. SPC přípravku Kaloba. www.sukl.cz (11. 12. 2025).

27. https://www.umckaloabo-stiftung.de/de (10. 12. 2025).