Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra


Autoři: Kai Rathje aff001;  Benedikt Mortzfeld aff001;  Marc P. Hoeppner aff003;  Jan Taubenheim aff001;  Thomas C. G. Bosch aff001;  Alexander Klimovich aff001
Působiště autorů: Zoological Institute, Kiel University, Kiel, Germany aff001;  Department of Biology, University of Massachusetts Dartmouth, Dartmouth, Massachusetts, United States of America aff002;  Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany aff003;  Institute for Zoology and Organismic Interactions, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany aff004
Vyšlo v časopise: Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra. PLoS Pathog 16(3): e1008375. doi:10.1371/journal.ppat.1008375
Kategorie: Research Article
doi: 10.1371/journal.ppat.1008375

Souhrn

The extent to which disturbances in the resident microbiota can compromise an animal’s health is poorly understood. Hydra is one of the evolutionary oldest animals with naturally occurring tumors. Here, we found a causal relationship between an environmental spirochete (Turneriella spec.) and tumorigenesis in Hydra. Unexpectedly, virulence of this pathogen requires the presence of Pseudomonas spec., a member of Hydra´s beneficial microbiome indicating that dynamic interactions between a resident bacterium and a pathogen cause tumor formation. The observation points to the crucial role of commensal bacteria in maintaining tissue homeostasis and adds support to the view that microbial community interactions are essential for disease. These findings in an organism that shares deep evolutionary connections with all animals have implications for our understanding of cancer.

Klíčová slova:

Bacteria – Carcinogenesis – Genome analysis – Hydra – Microbiome – Pathogen motility – Pseudomonas – Spirochetes


Zdroje

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