Timelines of infection and transmission dynamics of H1N1pdm09 in swine

Autoři: Laetitia Canini aff001;  Barbara Holzer aff002;  Sophie Morgan aff002;  Johanneke Dinie Hemmink aff002;  Becky Clark aff002;  ;  Mark E. J. Woolhouse aff001;  Elma Tchilian aff002;  Bryan Charleston aff003
Působiště autorů: Usher Institute, The University of Edinburgh, Edinburgh, United Kingdom aff001;  Mucosal immunology, Pirbright Institute, Woking, United Kingdom aff002;  Viral immunology, Pirbright Institute, Woking, United Kingdom aff003
Vyšlo v časopise: Timelines of infection and transmission dynamics of H1N1pdm09 in swine. PLoS Pathog 16(7): e32767. doi:10.1371/journal.ppat.1008628
Kategorie: Research Article
doi: 10.1371/journal.ppat.1008628


Influenza is a major cause of mortality and morbidity worldwide. Despite numerous studies of the pathogenesis of influenza in humans and animal models the dynamics of infection and transmission in individual hosts remain poorly characterized. In this study, we experimentally modelled transmission using the H1N1pdm09 influenza A virus in pigs, which are considered a good model for influenza infection in humans. Using an experimental design that allowed us to observe individual transmission events occurring within an 18-hr period, we quantified the relationships between infectiousness, shed virus titre and antibody titre. Transmission events was observed on 60% of occasions when virus was detected in donor pig nasal swabs and transmission was more likely when donor pigs shed more virus. This led to the true infectious period (mean 3.9 days) being slightly shorter than that predicted by detection of virus (mean 4.5 days). The generation time of infection (which determines the rate of epidemic spread) was estimated for the first time in pigs at a mean of 4.6 days. We also found that the latent period of the contact pig was longer when they had been exposed to smaller amount of shed virus. Our study provides quantitative information on the time lines of infection and the dynamics of transmission that are key parts of the evidence base needed to understand the spread of influenza viruses though animal populations and, potentially, in humans.

Klíčová slova:

Antibodies – Influenza – Influenza A virus – Influenza viruses – Natural history of disease – Pig models – Swine – Viral replication


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2020 Číslo 7

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