Authors: J. Čižmárik 2; M. Lachová 1; J. Lehotay 1; I. Skačáni 1 Authors‘ workplace: STU v Bratislave, Fakulta chemickej a potravinárskej technológie, Ústav analytickej chémie 1; Univerzita Komenského Bratislava, Farmaceutická fakulta, Katedra farmaceutickej chémie 2 Published in: Čes. slov. Farm., 2009; 58, 78-82 Category: Review Articles
Molecularly imprinted polymers for 1-methyl-2-piperidinoethylester of 2-methoxyphenylcarbamic acid (template) have been synthesised. Acrylamide and methacrylic acids, respectively, were used as the functional monomers. Imprinted polymers were used as the sorbents for solid-phase extraction (MISPE). The capacity and selectivity of prepared imprinted polymers were investigated with the use of some derivatives of 1-methyl-2-piperidinethylesters of alkoxyphenylcarbamic acids. The non-imprinted (blank) polymers were prepared by the same way without a template to study the non-specific interactions. The molecularly imprinted polymer prepared from methacrylic acid was used to preconcentrate 1-methyl-2-piperidinoethylester of 2-methoxyphenylcarbamic acid and its analogues from spiked human plasma (1 μg in 1 ml of plasma).
Key words: esters of alkoxyphenylcarbamic acids – HPLC – imprinted polymers – solid phase extraction
1. Pokorná, M., Čižmárik, J., Sedlárová, E., Račanská, E.: Čes. a slov. Farm., 1999; 45, 80–86.
2. Caro, E., Marcé, RM., Borrull, F., Cormack, PAG., Sherrington, D. C.: Trac – Trends Anal. Chem, 2006; 25, 143–154.
3. Sun, Z., Schüssler, W., Sengl, M., Niessner, R., Knopp, D.: Anal. Chim. Acta, 2008; 620, 73–81.
4. Yavuz, H., Karakoc, V., Türkmen, D., Say, R., Denizli, A.: Int. J. Biol. Macromol., 2007; 41, 8–15.
5. Shi, X., Wu, A., Zheng, S., Li, R., Zhang, D.: J. Chromatogr. B., 2007; 850, 24–30.
6. Peréz-Moral, N., Mayes, AG.: Biosens. Bioelectron., 2006; 21, 1798–1803.
7. Tasselli, F., Donato, L., Drioli, E. J.: J. Membr. Sci., 2008; 320, 167–172.
8. Turiel, E., Martín-Esteban, A., Tadeo, J. L.: J. Chromatogr. A., 2007; 1172, 97–104.
9. Haginaka, J., Tabo, H., Kagawa, C.: J. Pharm. Biomed. Analysis, 2008; 46, 877–881.
10. Fischer, L., Muller, R., Ekberg, B., Mosbach, K.: J. Am. Chem. Soc., 1991; 113, 9358–9360.
11. Pichon, V.: J Chromatogr. A., 2007; 1152, 41–53.
12. Ďungelová, J., Lehotay, J., Hroboňová, K., Čižmárik, J., Armstrong, D. W: J. Liq. Chromatogr., 2002; 25, 299–312.
13. Rojkovičová, T., Hroboňová, K., Lehotay, J., Čižmárik, J.: Pharmazie, 2003; 58, 108–110.
14. Zhang, T., Liu, F., Chen, W., Wang, J., Li, K.: Anal. Chim. Acta., 2001; 450, 53–61.
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