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The developmental genetic architecture of vocabulary skills during the first three years of life: Capturing emerging associations with later-life reading and cognition


Autoři: Ellen Verhoef aff001;  Chin Yang Shapland aff001;  Simon E. Fisher aff001;  Philip S. Dale aff006;  Beate St Pourcain aff001
Působiště autorů: Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands aff001;  International Max Planck Research School for Language Sciences, Nijmegen, The Netherlands aff002;  MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom aff003;  Population Health Sciences, University of Bristol, Bristol, United Kingdom aff004;  Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands aff005;  Speech & Hearing Sciences, University of New Mexico, Albuquerque, New Mexico, United States of America aff006
Vyšlo v časopise: The developmental genetic architecture of vocabulary skills during the first three years of life: Capturing emerging associations with later-life reading and cognition. PLoS Genet 17(2): e1009144. doi:10.1371/journal.pgen.1009144
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pgen.1009144

Souhrn

Individual differences in early-life vocabulary measures are heritable and associated with subsequent reading and cognitive abilities, although the underlying mechanisms are little understood. Here, we (i) investigate the developmental genetic architecture of expressive and receptive vocabulary in early-life and (ii) assess timing of emerging genetic associations with mid-childhood verbal and non-verbal skills. We studied longitudinally assessed early-life vocabulary measures (15–38 months) and later-life verbal and non-verbal skills (7–8 years) in up to 6,524 unrelated children from the population-based Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. We dissected the phenotypic variance of rank-transformed scores into genetic and residual components by fitting multivariate structural equation models to genome-wide genetic-relationship matrices. Our findings show that the genetic architecture of early-life vocabulary involves multiple distinct genetic factors. Two of these genetic factors are developmentally stable and also contribute to genetic variation in mid-childhood skills: One genetic factor emerging with expressive vocabulary at 24 months (path coefficient: 0.32(SE = 0.06)) was also related to later-life reading (path coefficient: 0.25(SE = 0.12)) and verbal intelligence (path coefficient: 0.42(SE = 0.13)), explaining up to 17.9% of the phenotypic variation. A second, independent genetic factor emerging with receptive vocabulary at 38 months (path coefficient: 0.15(SE = 0.07)), was more generally linked to verbal and non-verbal cognitive abilities in mid-childhood (reading path coefficient: 0.57(SE = 0.07); verbal intelligence path coefficient: 0.60(0.10); performance intelligence path coefficient: 0.50(SE = 0.08)), accounting for up to 36.1% of the phenotypic variation and the majority of genetic variance in these later-life traits (≥66.4%). Thus, the genetic foundations of mid-childhood reading and cognitive abilities are diverse. They involve at least two independent genetic factors that emerge at different developmental stages during early language development and may implicate differences in cognitive processes that are already detectable during toddlerhood.

Klíčová slova:

Genetic linkage – Genetic polymorphism – Genetics – Human genetics – Language – Phenotypes – Semantics – Vocabulary


Zdroje

1. Fenson L, Dale PS, Reznick JS, Bates E, Thal DJ, Pethick SJ. Variability in early communicative development. Monogr Soc Res Child Dev. 1994;59: 1–173; discussion 174–85. 7845413

2. Kennison SM. Introduction to language development. 1st ed. SAGA; 2014.

3. Clark EV. First language acquisition. New York: Cambridge University Press; 2016.

4. Goldfield BA, Reznick JS. Early lexical acquisition: rate, content, and the vocabulary spurt. J Child Lang. 1990;17: 171–183. doi: 10.1017/s0305000900013167 2312640

5. Fenson L, Dale P, Reznick JS, Thal D, Bates E, Hartung J, et al. User’s Guide and Technical Manual for the MacArthur Communicative Development Inventories. San Diego: Singular Publishing; 1993.

6. Burger A, Chong I. Receptive Vocabulary. In: Goldstein S, Naglieri JA, editors. Encyclopedia of Child Behavior and Development. Boston, MA: Springer US; 2011. pp. 1231–1231. doi: 10.1007/978-0-387-79061-9_2359

7. Owens Jr. R E. Language Development: An Introduction. 9 edition. Pearson; 2015.

8. Bergelson E, Swingley D. At 6–9 months, human infants know the meanings of many common nouns. Proc Natl Acad Sci USA. 2012;109: 3253–3258. doi: 10.1073/pnas.1113380109 22331874

9. Fenson L, Marchman VA. MacArthur-Bates Communicative Development Inventories: User’s Guide and Technical Manual. Paul H. Brookes Publishing Company; 2007.

10. Frank MC, Braginsky M, Yurovsky D, Marchman VA. Wordbank: an open repository for developmental vocabulary data. J Child Lang. 2017;44: 677–694. doi: 10.1017/S0305000916000209 27189114

11. Dionne G, Dale PS, Boivin M, Plomin R. Genetic Evidence for Bidirectional Effects of Early Lexical and Grammatical Development. Child Development. 2003;74: 394–412. doi: 10.1111/1467-8624.7402005 12705562

12. Dale PS, Dionne G, Eley TC, Plomin R. Lexical and grammatical development: a behavioural genetic perspective. Journal of Child Language. 2000;27: 619–642. null doi: 10.1017/s0305000900004281 11089341

13. Reznick JS, Corley R, Robinson J. A longitudinal twin study of intelligence in the second year. Monogr Soc Res Child Dev. 1997;62: i–vi, 1–154; discussion 155–60. 9185344

14. St Pourcain B, Cents RA, Whitehouse AJ, Haworth CM, Davis OS, O’Reilly PF, et al. Common variation near ROBO2 is associated with expressive vocabulary in infancy. Nature communications. 2014;5: 4831. doi: 10.1038/ncomms5831 25226531

15. Verhoef E, Shapland CY, Fisher SE, Dale PS, Pourcain BS. The developmental origins of genetic factors influencing language and literacy: Associations with early-childhood vocabulary. Journal of Child Psychology and Psychiatry. 2020. doi: 10.1111/jcpp.13327 32924135

16. Harlaar N, Hayiou-Thomas ME, Dale PS, Plomin R. Why Do Preschool Language Abilities Correlate With Later Reading? A Twin Study. J Speech Lang Hear Res. 2008;51: 688–705. doi: 10.1044/1092-4388(2008/049) 18506044

17. Hayiou-Thomas ME, Dale PS, Plomin R. The etiology of variation in language skills changes with development: a longitudinal twin study of language from 2 to 12 years. Dev Sci. 2012;15: 233–49. doi: 10.1111/j.1467-7687.2011.01119.x 22356179

18. Fraser A, Macdonald-Wallis C, Tilling K, Boyd A, Golding J, Davey Smith G, et al. Cohort Profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort. Int J Epidemiol. 2013;42: 97–110. doi: 10.1093/ije/dys066 22507742

19. Boyd A, Golding J, Macleod J, Lawlor DA, Fraser A, Henderson J, et al. Cohort Profile: the ‘children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children. Int J Epidemiol. 2013;42: 111–127. doi: 10.1093/ije/dys064 22507743

20. St Pourcain B, Eaves LJ, Ring SM, Fisher SE, Medland S, Evans DM, et al. Developmental changes within the genetic architecture of social communication behaviour: A multivariate study of genetic variance in unrelated individuals. Biological Psychiatry. 2017;83: 598–606. doi: 10.1016/j.biopsych.2017.09.020 29100628

21. Yang J, Lee SH, Goddard ME, Visscher PM. GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet. 2011;88: 76–82. doi: 10.1016/j.ajhg.2010.11.011 21167468

22. Curtin S, Archer SL. Speech perception. 2nd ed. In: Bavin EL, Naigles LR, editors. The Cambridge Handbook of Child Language. 2nd ed. Cambridge: Cambridge University Press; 2015. pp. 137–158. doi: 10.1017/CBO9781316095829.007

23. Hoff E. Language Development. Cengage Learning; 2013.

24. Bates E, Goodman JC. On the inseparability of grammar and the lexicon: Evidence from acquisition. Language development: The essential readings. Malden: Blackwell Publishing; 2001. pp. 134–162.

25. Silverman RD, Hartranft AM. Developing Vocabulary and Oral Language in Young Children. Guilford Publications; 2014.

26. Tomasello M, Mervis CB. The Instrument Is Great, but Measuring Comprehension Is Still a Problem. Monographs of the Society for Research in Child Development. 1994;59: 174–179. doi: 10.1111/j.1540-5834.1994.tb00186.x

27. Walters R, Churchhouse C, Hosking R. Heritability 101: What is “heritability”? 7 Aug 2019. Available: http://www.nealelab.is/blog/2017/9/13/heritability-101-what-is-heritability

28. Selzam S, Ritchie SJ, Pingault J-B, Reynolds CA, O’Reilly PF, Plomin R. Comparing Within- and Between-Family Polygenic Score Prediction. The American Journal of Human Genetics. 2019;105: 351–363. doi: 10.1016/j.ajhg.2019.06.006 31303263

29. Cheesman R, Hunjan A, Coleman JRI, Ahmadzadeh Y, Plomin R, McAdams TA, et al. Comparison of Adopted and Nonadopted Individuals Reveals Gene–Environment Interplay for Education in the UK Biobank: Psychological Science. 2020. doi: 10.1177/0956797620904450 32302253

30. Kong A, Thorleifsson G, Frigge ML, Vilhjalmsson BJ, Young AI, Thorgeirsson TE, et al. The nature of nurture: Effects of parental genotypes. Science. 2018;359: 424–428. doi: 10.1126/science.aan6877 29371463

31. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, et al. PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses. Am J Hum Genet. 2007;81: 559–575. doi: 10.1086/519795 17701901

32. Fenson L, Pethick S, Renda C, Cox JL, Dale PS, Reznick JS. Short-form versions of the MacArthur Communicative Development Inventories. Applied Psycholinguistics. 2000;21: 95–116. doi: 10.1017/S0142716400001053

33. Dale PS. The validity of a parent report measure of vocabulary and syntax at 24 months. J Speech Hear Res. 1991;34: 565–571. doi: 10.1044/jshr.3403.565 2072681

34. Ring ED, Fenson L. The correspondence between parent report and child performance for receptive and expressive vocabulary beyond infancy. First Language. 2000;20: 141–159. doi: 10.1177/014272370002005902

35. WORD, Wechsler Objective Reading Dimensions Manual. Psychological Corporation; 1993.

36. Wechsler D, Golombok S, Rust J. WISC-III UK Wechsler Intelligence Scale for Children–Third Edition UK Manual. Sidcup, UK: The Psychological Corporation; 1992.

37. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics. 2006;38: 904–909. doi: 10.1038/ng1847 16862161

38. Brooks R, Meltzoff AN. Infant gaze following and pointing predict accelerated vocabulary growth through two years of age: a longitudinal, growth curve modeling study. J Child Lang. 2008;35: 207–220. doi: 10.1017/s030500090700829x 18300435

39. Beasley TM, Erickson S, Allison DB. Rank-Based Inverse Normal Transformations are Increasingly Used, But are They Merited? Behav Genet. 2009;39: 580–595. doi: 10.1007/s10519-009-9281-0 19526352

40. Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, et al. Common SNPs explain a large proportion of the heritability for human height. Nat Genet. 2010;42: 565–569. doi: 10.1038/ng.608 20562875

41. Lee SH, Yang J, Goddard ME, Visscher PM, Wray NR. Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood. Bioinformatics. 2012;28: 2540–2542. doi: 10.1093/bioinformatics/bts474 22843982

42. Martin NG, Eaves LJ. The genetical analysis of covariance structure. Heredity (Edinb). 1977;38: 79–95. doi: 10.1038/hdy.1977.9 268313

43. Neale M, Maes HHM. Methodology for genetic studies of twins and families. Dordrecht: Kluwer Academic Publisher; 2004.

44. Neale M, Boker S, Xie G, Maes HHM. Mx: Statistical modeling. 7th ed. Richmond: Department of Psychiatry; 2006.


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