PLOS Genetics - Číslo 1/2015


The Combination of Random Mutagenesis and Sequencing Highlight the Role of Unexpected Genes in an Intractable Organism
Ataxin-3, DNA Damage Repair, and SCA3 Cerebellar Degeneration: On the Path to Parsimony?
α-Actinin-3: Why Gene Loss Is an Evolutionary Gain
Regulating Maf1 Expression and Its Expanding Biological Functions
A Polyubiquitin Chain Reaction: Parkin Recruitment to Damaged Mitochondria


End of the Beginning: Elongation and Termination Features of Alternative Modes of Chromosomal Replication Initiation in Bacteria
The Genetic and Mechanistic Basis for Variation in Gene Regulation

Research Article

Origins of Context-Dependent Gene Repression by Capicua
Transposable Elements Contribute to Activation of Maize Genes in Response to Abiotic Stress
No Evidence for Association of Autism with Rare Heterozygous Point Mutations in Contactin-Associated Protein-Like 2 (), or in Other Contactin-Associated Proteins or Contactins
Nur1 Dephosphorylation Confers Positive Feedback to Mitotic Exit Phosphatase Activation in Budding Yeast
A Regulatory Hierarchy Controls the Dynamic Transcriptional Response to Extreme Oxidative Stress in Archaea
Genetic Variants Modulating CRIPTO Serum Levels Identified by Genome-Wide Association Study in Cilento Isolates
Small RNA Sequences Support a Host Genome Origin of Satellite RNA
Phosphorylation of Elp1 by Hrr25 Is Required for Elongator-Dependent tRNA Modification in Yeast
Genetic Mapping of MAPK-Mediated Complex Traits Across
An AP Endonuclease Functions in Active DNA Demethylation and Gene Imprinting in
Developmental Regulation of the Origin Recognition Complex
Naturally Occurring Differences in CENH3 Affect Chromosome Segregation in Zygotic Mitosis of Hybrids
Imputation of the Rare G84E Mutation and Cancer Risk in a Large Population-Based Cohort
Polycomb Protein SCML2 Associates with USP7 and Counteracts Histone H2A Ubiquitination in the XY Chromatin during Male Meiosis
A Genetic Strategy for Probing the Functional Diversity of Magnetosome Formation
Interactions of Chromatin Context, Binding Site Sequence Content, and Sequence Evolution in Stress-Induced p53 Occupancy and Transactivation
The Yeast La Related Protein Slf1p Is a Key Activator of Translation during the Oxidative Stress Response
Integrative Analysis of DNA Methylation and Gene Expression Data Identifies as a Key Regulator of COPD
Proteasomes, Sir2, and Hxk2 Form an Interconnected Aging Network That Impinges on the AMPK/Snf1-Regulated Transcriptional Repressor Mig1
Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break
Estrogenic Exposure Alters the Spermatogonial Stem Cells in the Developing Testis, Permanently Reducing Crossover Levels in the Adult
Protein Poly(ADP-ribosyl)ation Regulates Immune Gene Expression and Defense Responses
Sumoylation Influences DNA Break Repair Partly by Increasing the Solubility of a Conserved End Resection Protein
A Discrete Transition Zone Organizes the Topological and Regulatory Autonomy of the Adjacent and Genes
Elevated Mutation Rate during Meiosis in
The Intersection of the Extrinsic Hedgehog and WNT/Wingless Signals with the Intrinsic Hox Code Underpins Branching Pattern and Tube Shape Diversity in the Airways
MiR-24 Is Required for Hematopoietic Differentiation of Mouse Embryonic Stem Cells
Tissue-Specific Effects of Genetic and Epigenetic Variation on Gene Regulation and Splicing
Heterologous Aggregates Promote Prion Appearance via More than One Mechanism
The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway
, A -Acting Locus that Controls Chromosome-Wide Replication Timing and Stability of Human Chromosome 15
RecFOR Is Not Required for Pneumococcal Transformation but Together with XerS for Resolution of Chromosome Dimers Frequently Formed in the Process
An Intracellular Transcriptomic Atlas of the Giant Coenocyte
Insight in Genome-Wide Association of Metabolite Quantitative Traits by Exome Sequence Analyses
The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis
The Global Regulatory Architecture of Transcription during the Cell Cycle
Identification and Functional Characterization of Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the Locus
Altered Ca Kinetics Associated with α-Actinin-3 Deficiency May Explain Positive Selection for Null Allele in Human Evolution
Genetic Variation in the Nuclear and Organellar Genomes Modulates Stochastic Variation in the Metabolome, Growth, and Defense
PRDM9 Drives Evolutionary Erosion of Hotspots in through Haplotype-Specific Initiation of Meiotic Recombination
Transcriptional Control of an Essential Ribozyme in Reveals an Ancient Evolutionary Divide in Animals
ALIX and ESCRT-III Coordinately Control Cytokinetic Abscission during Germline Stem Cell Division
Century-scale Methylome Stability in a Recently Diverged Lineage
A Re-examination of the Selection of the Sensory Organ Precursor of the Bristle Sensilla of
Antagonistic Cross-Regulation between Sox9 and Sox10 Controls an Anti-tumorigenic Program in Melanoma
A Dependent Pool of Phosphatidylinositol 4,5 Bisphosphate (PIP) Is Required for G-Protein Coupled Signal Transduction in Photoreceptors
Deciphering the Genetic Programme Triggering Timely and Spatially-Regulated Chitin Deposition
Aberrant Gene Expression in Humans
Fascin1-Dependent Filopodia are Required for Directional Migration of a Subset of Neural Crest Cells
The SWI2/SNF2 Chromatin Remodeler BRAHMA Regulates Polycomb Function during Vegetative Development and Directly Activates the Flowering Repressor Gene
Evolutionary Constraint and Disease Associations of Post-Translational Modification Sites in Human Genomes
A Truncated NLR Protein, TIR-NBS2, Is Required for Activated Defense Responses in the Mutant
Inactivation of PNKP by Mutant ATXN3 Triggers Apoptosis by Activating the DNA Damage-Response Pathway in SCA3
DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining
hnRNP K Coordinates Transcriptional Silencing by SETDB1 in Embryonic Stem Cells

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