Communicating the Results of Clinical Research to Participants: Attitudes, Practices, and Future Directions


article has not abstract


Published in the journal: . PLoS Med 5(5): e91. doi:10.1371/journal.pmed.0050091
Category: Guidelines and Guidance
doi: https://doi.org/10.1371/journal.pmed.0050091

Summary

article has not abstract

Recent commentaries advocate routinely offering study results to research participants [1,2]. However, debate continues over the scope and limits of investigators' responsibilities in this regard. A 2006 review identified 30 national and international policies and guidelines concerning the duty to return research results [3], of which 21 were published in the last decade. Worldwide interest in this complex issue will likely continue to rise in light of the increasing relevance of the results of biomedical research to participants' health and well-being.

Unfortunately, many policies and commentaries on communication of results either do not adequately take into account relevant available data, or fail to recognize the lack thereof. For example, existing data on participant desire and investigator support for communication of research results have not been synthesized, nor have the data on potential positive and negative consequences that communication of results may have for both participants and researchers.

The results of clinical research may be classified as either aggregate study results, representing synthesized data and conclusions drawn from groups of research participants, or individual results, representing distinct items of data collected from or about individual participants. In this article, we present a narrative review of available data on the effects of communicating aggregate and individual research results on participants, investigators, and the research enterprise. We also present available data on disclosure practices and the attitudes of investigators and participants towards communication of research results. Our aim is not to provide definitive analyses of any of these domains; rather, it is to highlight trends in the literature as well as areas that require further investigation.

Data on Communicating Research Results

A literature search revealed 28 empirical studies concerning communication of research results (Text S1). Because these studies encompass many different participant populations and research settings, we did not pool quantitative data or conduct a formal quality assessment of studies. Of the 28 studies summarized below, 22 are primarily quantitative and six are primarily qualitative [4–9]. Sample size ranged from 13 [7] to 8,941 [8]. Twelve studies involved either cancer research or the attitudes of patients with cancer [7,10–20]; seven studies involved genetics research [7,9,11,20–23]. Ten studies were conducted in the United States [9,10,16–21,24,25], nine in the United Kingdom [4–8,11,26–28], four in Canada [14,15,29,30], one in France [23], and one in Sweden [22]. Three studies enrolled a multinational participant population [12,13,31].

Participant attitudes towards disclosure.

Eighteen studies provided empirical data on participants' desire to receive study results [5–11,14–16,18–23,27,32]. Nine studies involved aggregate study results, eight involved individual results, and one involved both (Table 1). Of studies that reported desire to receive results as a percentage of respondents, a median of 90% (range 20%–100%) wished to receive study results. In studies not reporting percentages, mothers of pediatric patients with cancer rated the importance of aggregate study results at a mean of 4.5 of a maximum importance of 5 [10], parents of infants in a randomized controlled trial of extracorporeal membrane oxygenation (ECMO) “felt strongly they should be sent the trial results” [5], and relatives of deceased patients with prostate cancer stated that they “had a right to know information that they could use to make personal risk management decisions” [7]. When asked an open-ended question about their experience in a study allowing them to access their individual obstetric records, 99 of 247 pregnant women volunteered a desire to receive aggregate study results without being prompted [6].

Tab. 1. Participant Desire for Study Results
Participant Desire for Study Results
aType of research results targeted by the named study: A = aggregate study results, I = individual results, B = both.

Nine studies assessed participants' reasons for wanting aggregate or individual study results. Participants in these studies cited clinical significance (e.g., treatment, prevention, or understanding of a disease) for self or relatives [7–11,23], respect for participants in research or a “right” to receive results [5,11,14], and raising public awareness of research [14]. Interestingly, Wendler et al. reported that the mere fact that investigators have information about participants that participants lack contributes to the desire to receive individual research results [20]. In a study by Fernandez et al., participants suggested that the possibility of causing distress to families of deceased participants or situations in which participants were harmed or not helped by the research could be reasons for not disclosing research results [14]. However, Partridge et al. reported that participants wanted to be contacted with aggregate results even if they were not helped by the research [16].

Ten studies [5,8–11,14–16,18,19] assessed participants' preferences for the method of receiving research results. Two prospective studies of adolescent patients with cancer and parents of children with cancer by Fernandez et al. report that (1) 60% of participants felt communication of results by mail would be satisfactory, though 50% stated that they would prefer face-to-face contact [15]; and (2) approximately 75% of participants would prefer to receive results with positive or neutral implications by letter or e-mail, while approximately 53% of participants would prefer to have results with negative implications communicated in person [14]. Participants in a longitudinal genetic database were “relatively open with regards to how they would prefer to be recontacted” with individual results [9], and participants in a clinical treatment trial for breast cancer preferred that their physicians communicate the aggregate results of clinical trials in which they participated [16].

Participants were asked to retrospectively evaluate written communication of research results in five studies [5,8,10,18,19]. Mothers of child participants in an epidemiological study of brain tumors found written aggregate study results understandable and important; however, 40% wanted a phone number to call with questions [10]. Written notification of aggregate study results with contact numbers was also the preferred method of communication for retinoblastoma survivors and participants in a trial of antibiotics during pregnancy [8,19]. In addition, 74% of women informed by mail of the early stoppage of a phase II trial of breast excision for ductal carcinoma in situ felt comfortable with this method of notification [18]. However, parents of infants who had taken part in a clinical trial of ECMO reported mixed experiences with receiving written communication about aggregate study results, as many felt the information was either too complex or too simplistic [5].

Investigator attitudes and practices regarding disclosure.

Five studies assessed investigators' support for communicating research results to participants [4,12,17,26,31]. Four studies involved aggregate study results and one involved individual results (Table 2). A substantial majority of investigators surveyed in four studies supported communicating study results to participants [12,17,26,31]. In the remaining study, only one-third of six midwives and ten physicians surveyed favored the communication of clinical trial results regarding fetal heart monitoring techniques [4].

Tab. 2. Investigators' Support for Communicating Research Results
Investigators' Support for Communicating Research Results
aType of research results targeted by the named study: A = aggregate study results, I = individual results.

Cancer investigators identified the cost and time involved in preparing a lay summary as well as difficulty in contacting participants as major barriers to communicating aggregate study results [12]. Clinical investigators also identified possible biasing of study follow-ups and cost as major barriers to communicating individual results [26]. In both cases, a minority of investigators identified negative psychological consequences as a perceived barrier to communication of research results [12,26]. Cancer clinicians in another study expressed a reluctance to inform participants of negative study conclusions owing to a desire to protect participants from harmful psychological consequences [17].

The chairs of Canadian research ethics boards (REBs) overwhelmingly supported offering research results after the conclusion of the study [30], and the monitoring committee of a pharmacogenetics study involving HIV-infected patients strongly favored communicating results of “direct benefit” to the participant, but expressed doubts regarding the communication of other results [23].

Six studies assessed the practices and policies of investigators and institutions concerning the communication of research results to participants [12,13,17,26,29,31]. Four studies involved aggregate study results, one study involved individual results, and one involved both (Table 3). Communicating research results seems to represent the exception to practice. For example, only five of 150 institutions surveyed by Fernandez et al. had a formal mechanism for returning research results to participants [12], and only 3% of 180 consent forms for leukemia clinical trials indicated that participants could receive study results [13]. Furthermore, only nine of 22 Canadian REBs surveyed had policies addressing communication of results or required investigators to address the issue themselves [29].

Tab. 3. Research Results Communication Practices
Research Results Communication Practices
aType of research results targeted by the named study: A = aggregate study results, I = individual results, B = both.

Impact of disclosure on participants.

Eight studies empirically assessed the impact of receiving study results, all of which involved aggregate results [5,7,8,10,11,18,19,24] (Table 4). These studies used various methods of assessing participants' reactions to receiving study information, including interviews [5,7,8,11], Likert scales of possible psychological reactions [10,19], the revised Impact of Event Scale [18], and the McMaster Health Index Questionnaire [24]. All but one study [24] reported some incidence of negative psychological consequences for participants, including increased anxiety, anger, guilt, or upset. However, six studies [5,7,8,10,19,24] reported psychological benefits for participants from receiving research results, including pleasure, satisfaction, and relief.

Tab. 4. Impact on Participants of Receiving Research Results
Impact on Participants of Receiving Research Results
aType of research results targeted by the named study: A = aggregate study results.

Importantly, the vast majority of participants reported feeling that it was important to receive study results, despite potentially negative emotional impact (Table 1). For example, Schulz et al. [19] reported that approximately a quarter of retinoblastoma survivors or parents of children with retinoblastoma indicated that receiving aggregate study results regarding their risk of developing second malignancies made them “very” to “extremely” frightened, anxious, or sad. However, 20% of participants were “very” to “extremely” relieved by the results, and only 1.4% of participants in this study would have preferred not to receive results.

Three studies examined correlations between education and psychological impact of disclosure: one found that participants with less than a college education were significantly more sad, angry, overwhelmed, or frightened than those with a college education [19], one found the opposite [18], and one found no correlation between educational level and psychological impact of disclosure [10].

Only the study by Schulz et al. addressed clinical follow-up after receiving research data [19]. The study authors found that despite their recommendations, only 18% of participants spoke with their physicians about the disclosed results, 16% of survivors attended cancer screening check-ups, and 12% of parents of child retinoblastoma survivors took their children to be screened. The authors hypothesized that the impersonal nature of written communication may have led to poor utilization of clinically significant information.

Impact of disclosure on investigators.

One study addressed the costs of communicating research results. Dinnett et al. reported that expenses associated with communicating treatment allocation and lipid profiles to participants included preparation, printing, and distribution of letters as well as additional salary support for existing staff. The authors also report receiving only 21 phone calls after unblinding 1,391 participants [28].

Impact of disclosure on the research enterprise.

Buchwald et al. show trends (p-values between 0.09 and 0.13) indicating that after communication of aggregate study results, 726 participants were more likely to be (1) satisfied with their decision to enroll, (2) satisfied with randomization allocation, and (3) disposed to advise others to join a research study after communication of aggregate study results [24]. Snowdon et al. report that of 31 parents notified of their infant's allocation to the ECMO or standard care groups in a completed clinical trial, few said that this information affected their view of the trial, randomization, or their doctor [5].

Discussion

As we have conducted a narrative review of studies concerning communicating research results to participants, rather than a systematic review, definitive conclusions about findings and their ethical import cannot be drawn. Nevertheless, the data reviewed here suggest several important implications. Available data consistently indicate that research participants want aggregate and clinically significant individual study results made available to them. Participants' desires do not necessarily determine policy, but respect for participants requires taking their preferences seriously. Though investigators appear to support the communication of aggregate study results, less is known about investigators' attitudes towards communicating individual research results or about the costs and time required to do so. Future research should focus on these issues, including ways to facilitate communication of results by addressing investigators' concerns.

It may be helpful to consider the significant body of literature from the 1990s concerning worker notification of research showing increased occupational health risk [10]. Employers initially resisted notifying workers of risk, citing concerns of causing unduly negative psychological reactions as well as affecting workers' insurability, employability, and credit rating [33–36]. Subsequent research showed little evidence that notification of occupational health risks leads to significant long- or short-term psychological consequences [37–39]. One study also reported that after 3,189 notification letters were mailed containing a toll-free number for additional information, only 40 calls were received, suggesting that cost of follow-up after communication of results may not be especially burdensome [40]. Authors in the occupational health literature have carefully assessed the method, timing, and content of risk-notification procedures; clinical investigators considering how to approach communication of research results may find these analyses and the lessons learned useful [34,40–46].

Both the clinical research and occupational health literature demonstrate that some participants will show positive and/or negative psychological changes after receiving research results. However, studies of the psychological impact of genetic testing demonstrate that individuals tend to exhibit less emotional distress than anticipated by clinicians, and show strong coping skills in dealing with undesired results [47–50]. Likewise, the balance of evidence suggests that false reassurance is not a significant problem for the communication of research results [51–55]. Three studies that identify false reassurance suggest that inadequacies in explaining results may be to blame, and recommend that, in the case of genetic testing, the implications of positive and negative results be emphasized equally [56–58]. The impact of communicated study results may also vary by study type and characteristics of the participant population, including diagnoses, health status, education, and health literacy. Investigators should therefore tailor their communication practices with respect to the situation and needs of their intended audience. Future research should assess the effect of various modes of communicating research results on psychological sequelae, health behaviors, and understanding of results by participants. Importantly, despite the potential for negative psychological consequences, participants want the opportunity to receive research results. These data suggest that fear of psychological harm should not be used as a reason not to offer research results, without clear evidence of a threat to participants' safety.

The costs of communicating research results to a study population remain unknown. However, in the absence of data, two points should be considered. First, concerns over cost of disclosure often stem from the assumption that research results must be communicated in person, and in the case of genetics research, by trained genetic counselors. Though in some cases, in-person disclosure may encourage follow-through on clinical recommendations and discourage false reassurance, participants often prefer to receive results in writing with contact information. Second, although there will undoubtedly be some expenditure associated with communicating research results, cost should not be used as an argument against routine offering of study results to participants unless communicating results would substantially compromise the feasibility of the research. Future research should therefore assess the actual cost of various communication strategies.

It remains unclear whether communicating research results to participants will significantly affect participants' perception of investigators and biomedical research, or influence their likelihood of enrolling in future studies. More empirical data will be needed to resolve this issue; however, participants tend to be grateful when they receive study results, suggesting that such communication may bolster public opinion of investigators and the research they conduct.

Our analysis of the empirical literature on disclosure of research results to participants also revealed that the impact of presenting aggregate results to participants may equal that of presenting individual results. For example, while post-trial disclosure of treatment randomization or communication of individual genotypes may be clear examples of information relevant to individual participants, aggregate results of epidemiological studies may be just as individually relevant if participants know their own risk factors. Furthermore, many studies we found did not explicitly identify a focus on aggregate study results, individual results, or both. As communicating these two types of results may pose different practical and ethical challenges, researchers should specify the type(s) of results under consideration.

The literature on communication of research results is limited by a lack of commonly used and well-validated measures for most outcomes of interest. This limitation may be especially problematic given that framing effects can result in widely differing estimates of preferences, attitudes, and impact. Additionally, detailed data extraction is often impossible when the impact of disclosure on participants is reported either qualitatively or using a Likert scale. It will therefore be necessary to employ rigorous study designs (e.g., controlled trials and longitudinal studies) to assess the effects of communicating research results. Finally, 16 of the 28 studies we identified involved either cancer or genetics research. Future research should consider issues specific to other clinical research settings as well as to sociobehavioral research.

As discussion and research move forward, we recommend that investigators include their planned approach to communicating aggregate and individual results in study protocols and address disclosure in informed consent documents. Research ethics committees should review the appropriateness of investigators' plans for communicating results. Much still rests, however, on careful examination of the ethical issues involved in determining investigators' responsibilities for communicating research results to participants. Policies should incorporate available empirical data into an ethical framework that (1) respects and supports the collaborative relationship between investigators and research participants and (2) enhances trust in, and trustworthiness of, research and researchers.

Supporting Information

Attachment 1


Zdroje

1. FernandezCVKodishEWeijerC

2003

Informing study participants of research results: An ethical imperative.

IRB

25

12

9

2. ShalowitzDIMillerFG

2005

Disclosing individual results of clinical research: Implications of respect for participants.

JAMA

294

737

740

3. KnoppersBMJolyYSimardJDurocherF

2006

The emergence of an ethical duty to disclose genetic research results: International perspectives.

Eur J Hum Genet

14

1170

1178

4. GarciaJ

1987

Sharing research results with patients: The views of care-givers involved in a randomized controlled trial.

J Reprod Infant Psychol

5

9

13

5. SnowdonCGarciaJElbourneD

1998

Reactions of participants to the results of a randomised controlled trial: Exploratory study.

BMJ

317

21

26

6. ElbourneD

1987

Subjects' views about participation in a randomized controlled trial.

J Reprod Infant Psychol

5

3

8

7. OrmondroydEMoynihanCWatsonMFosterCDavollsS

2007

Disclosure of genetics research results after the death of the patient participant: A qualitative study of the impact on relatives.

J Genet Couns

16

527

538

8. Dixon-WoodsMJacksonCWindridgeKCKenyonS

2006

Receiving a summary of the results of a trial: Qualitative study of participants' views.

BMJ

332

206

210

9. OrmondKESmithMECirinoALChisholmRLWolfWA

2004

“Duty” to recontact participants in a population based genetic database: The NUgene experience.

American College of Medical Genetics Annual Conference; 6 March 2004; Kissimmee, Florida, United States

10. BuninGRKazakAEMitelmanO

1996

Informing subjects of epidemiologic study results. Children's Cancer Group.

Pediatrics

97

486

491

11. RichardsMPPonderMPharoahPEverestSMackayJ

2003

Issues of consent and feedback in a genetic epidemiological study of women with breast cancer.

J Med Ethics

29

93

96

12. FernandezCVKodishEShurinSWeijerC

2003

Offering to return results to research participants: Attitudes and needs of principal investigators in the Children's Oncology Group.

J Pediatr Hematol Oncol

25

704

708

13. FernandezCVKodishETaweelSShurinSWeijerC

2003

Disclosure of the right of research participants to receive research results: An analysis of consent forms in the Children's Oncology Group.

Cancer

97

2904

2909

14. FernandezCVSantorDWeijerCStrahlendorfCMoghrabiA

2007

The return of research results to participants: Pilot questionnaire of adolescents and parents of children with cancer.

Pediatr Blood Cancer

48

441

446

15. FernandezCVTaweelSKodishEWeijerC

2005

Disclosure of research results to research participants: A pilot study of the needs and attitudes of adolescents and parents.

Paediatr Child Health

10

332

334

16. PartridgeAHBursteinHJGelmanRSMarcomPKWinerEP

2003

Do patients participating in clinical trials want to know study results.

J Natl Cancer Inst

95

491

492

17. PartridgeAHHackettNBloodEGelmanRJoffeS

2004

Oncology physician and nurse practices and attitudes regarding offering clinical trial results to study participants.

J Natl Cancer Inst

96

629

632

18. PartridgeAHWongJSKnudsenKGelmanRSampsonE

2005

Offering participants results of a clinical trial: Sharing results of a negative study.

Lancet

365

963

964

19. SchulzCJRiddleMPValdimirsdottirHBAbramsonDHSklarCA

2003

Impact on survivors of retinoblastoma when informed of study results on risk of second cancers.

Med Pediatr Oncol

41

36

43

20. WendlerDPentzR

2007

How does the collection of genetic test results affect research participants.

Am J Med Genet A

143

1733

1738

21. FongMBraunKLChangRM

2004

Native Hawaiian preferences for informed consent and disclosure of results from research using stored biological specimens.

Pac Health Dialog

11

154

159

22. HoeyerKOlofssonBOMjorndalTLynoeN

2004

Informed consent and biobanks: A population-based study of attitudes towards tissue donation for genetic research.

Scand J Public Health

32

224

229

23. MoutelGDuchangeNRaffiFShararaLITheodorouI

2005

Communication of pharmacogenetic research results to HIV-infected treated patients: Standpoints of professionals and patients.

Eur J Hum Genet

13

1055

1062

24. BuchwaldHFitchLLMattsJPJohnsonJWHansenBJ

1993

Perception of quality of life before and after disclosure of trial results: A report from the Program on the Surgical Control of the Hyperlipidemias (POSCH).

Control Clin Trials

14

500

510

25. WendlerDPrasadKWilfondB

2002

Does the current consent process minimize the risks of genetics research.

Am J Med Genet

113

258

262

26. Di BlasiZKaptchukTJWeinmanJKleijnenJ

2002

Informing participants of allocation to placebo at trial closure: Postal survey.

BMJ

325

1329

27. DinnettEMMungallMMGordonCRonaldESGawA

2006

Offering results to research participants.

BMJ

332

549

550

28. DinnettEMMungallMMKentJARonaldESMcIntyreKE

2005

Unblinding of trial participants to their treatment allocation: Lessons from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER).

Clin Trials

2

254

259

29. MacneilSDFernandezCV

2006

Informing research participants of research results: Analysis of Canadian university based research ethics board policies.

J Med Ethics

32

49

54

30. MacNeilSDFernandezCV

2007

Attitudes of research ethics board chairs towards disclosure of research results to participants: Results of a national survey.

J Med Ethics

33

549

553

31. RigbyHFernandezCV

2005

Providing research results to study participants: Support versus practice of researchers presenting at the American Society of Hematology annual meeting.

Blood

106

1199

1202

32. WendlerDEmanuelE

2002

The debate over research on stored biological samples: What do sources think.

Arch Intern Med

162

1457

1462

33. BayerR

1986

Notifying workers at risk: The politics of the right-to-know.

Am J Public Health

76

1352

1356

34. SchultePABoalWLFriedlandJMWalkerJTConnallyLB

1993

Methodologic issues in risk communications to workers.

Am J Ind Med

23

3

9

35. RingenK

1989

The case for worker notification.

Ann N Y Acad Sci

572

133

141

discussion 142–143

36. WoodFB

1990

Letter submitted to NIOSH by Westinghouse Electric Corporation as part of a panel of experts' analysis regarding interim report.

HETA

89

116

37. HornsbyJLSappingtonJTMonganPGullenWHBonoSF

1985

Risk for bladder cancer. Psychological impact of notification.

JAMA

253

1899

1902

38. HoutsPSMcDougallV

1988

Effects of informing workers of their health risks from exposure to toxic materials.

Am J Ind Med

13

271

279

39. MeyerowitzBESullivanCDPremeauCL

1989

Reactions of asbestos-exposed workers to notification and screening.

Am J Ind Med

15

463

475

40. MazzuckelliLFSchultePA

1993

Notification of workers about an excess of malignant melanoma: A case study.

Am J Ind Med

23

85

91

41. KumekawaESLashAABeckerCE

1992

Challenges of worker notification in neurotoxic studies of the central nervous system.

Environ Res

59

125

131

42. LashAAKumekawaESBeckerCE

1993

Evaluating the clarity of research reports written for research subjects.

Am J Ind Med

23

211

219

43. MeyerowitzBE

1993

Assessing quality of life when planning and evaluating worker notification programs: Two case examples.

Am J Ind Med

23

221

227

44. NeedlemanC

1993

Social aspects of high-risk notification among chromium-exposed workers.

Am J Ind Med

23

113

123

45. NeedlemanC

1993

Worker notification: Lessons from the past.

Am J Ind Med

23

11

23

46. RudolphL

1993

Issues in notification: Reflections of a public health worker.

Am J Ind Med

23

53

59

47. BroadstockMMichieSMarteauT

2000

Psychological consequences of predictive genetic testing: A systematic review.

Eur J Hum Genet

8

731

738

48. LermanCCroyleRTTercyakKPHamannH

2002

Genetic testing: Psychological aspects and implications.

J Consult Clin Psychol

70

784

797

49. SmithCOLipeHPBirdTD

2004

Impact of presymptomatic genetic testing for hereditary ataxia and neuromuscular disorders.

Arch Neurol

61

875

880

50. SteinbartEJSmithCOPoorkajPBirdTD

2001

Impact of DNA testing for early-onset familial Alzheimer disease and frontotemporal dementia.

Arch Neurol

58

1828

1831

51. DorvalMGauthierGMaunsellEDugasMJRouleauI

2005

No evidence of false reassurance among women with an inconclusive BRCA1/2 genetic test result.

Cancer Epidemiol Biomarkers Prev

14

2862

2867

52. DrossaertCHBoerHSeydelER

2001

Does mammographic screening and a negative result affect attitudes towards future breast screening.

J Med Screen

8

204

212

53. MarteauTMKinmonthALThompsonSPykeS

1996

The psychological impact of cardiovascular screening and intervention in primary care: A problem of false reassurance? British Family Heart Study Group.

Br J Gen Pract

46

577

582

54. MarteauTMRobertsSLaRusseSGreenRC

2005

Predictive genetic testing for Alzheimer's disease: Impact upon risk perception.

Risk Anal

25

397

404

55. van DijkSOttenWTimmermansDRvan AsperenCJMeijers-HeijboerH

2005

What's the message? Interpretation of an uninformative BRCA1/2 test result for women at risk of familial breast cancer.

Genet Med

7

239

245

56. JohnsonKATrimbathJDPetersenGMGriffinCAGiardielloFM

2002

Impact of genetic counseling and testing on colorectal cancer screening behavior.

Genet Test

6

303

306

57. LermanCMarshallJAudrainJGomez-CamineroA

1996

Genetic testing for colon cancer susceptibility: Anticipated reactions of patients and challenges to providers.

Int J Cancer

69

58

61

58. ClausenHBrandtNJSchwartzMFlemmingS

1996

Psychological impact of carrier screening for cystic fibrosis among pregnant women.

Eur J Hum Genet

4

120

123

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