Emergomyces: The global rise of new dimorphic fungal pathogens

English version

Autoři: Ilan S. Schwartz ^aff001; Nelesh P. Govender ^aff002; Lynne Sigler ^aff004; Yanping Jiang ^aff005; Tsidiso G. Maphanga ^aff002; Barbra Toplis ^aff008; Alfred Botha ^aff008; Karolina Dukik ^aff005; J. Claire Hoving ^aff009; Jose F. Muñoz ^aff010; Sybren de Hoog ^aff005; Christina A. Cuomo ^aff010; Robert Colebunders ^aff012; Chris Kenyon ^aff013
Působiště autorů: Division of Infectious Diseases, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada ^aff001; National Institute for Communicable Diseases, a Division of the National Health Laboratory Service, Johannesburg, Gauteng, South Africa ^aff002; Department of Clinical Microbiology and Infectious Diseases, University of the Witwatersrand, Johannesburg, Gauteng, South Africa ^aff003; Department of Biological Sciences, Faculty of Sciences, University of Alberta, Edmonton, Alberta, Canada ^aff004; Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands ^aff005; Department of Dermatology, The Affiliated Hospital, Guizhou Medical University, Guiyang, China ^aff006; University of the Free State, Bloemfontein, Free State, South Africa ^aff007; Department of Microbiology, Stellenbosch University, Stellenbosch, Western Cape, South Africa ^aff008; Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, Western Cape, South Africa ^aff009; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America ^aff010; Center of Expertise in Mycology of RadboudUMC/ Canisius Wilhelmina Hospital, Nijmegen, The Netherlands ^aff011; Global Health Institute, University of Antwerp, Antwerp, Belgium ^aff012; Clinical Sciences Unit, Institute of Tropical Medicine, Antwerp, Belgium ^aff013; Department of Medicine, University of Cape Town, Cape Town, Western Cape, South Africa ^aff014
Vyšlo v časopise: Emergomyces: The global rise of new dimorphic fungal pathogens. PLoS Pathog 15(9): e32767. doi:10.1371/journal.ppat.1007977
Kategorie: Pearls
doi: https://doi.org/10.1371/journal.ppat.1007977

Zdroje

1. Gori S, Drouhet E, Gueho E, Huerre M, Lofaro A, Parenti M, et al. Cutaneous disseminated mycosis in a patient with AIDS due to a new dimorphic fungus. J Mycol Med. 1998;8(2):57–63.

2. Drouhet E, Gueho E, Gori S, Huerre M, Provost F, Borgers M, et al. Mycological, ultrastructural and experimental aspects of a new dimorphic fungus, Emmonsia pasteuriana sp. nov. isolated from a cutaneous disseminated mycosis in AIDS. J Mycol Med. 1998;8(2):64–77.

3. Sigler L. Adiaspiromycosis and other infections caused by Emmonsia species. In: Hay RJ, Merz WG, editors. Topley and Wilson's Microbiology and Microbial Infections. 10th ed. London, U.K.: Arnold Hodder; 2005. p. 809–24.

4. Kenyon C, Bonorchis K, Corcoran C, Meintjes G, Locketz M, Lehloenya R, et al. A dimorphic fungus causing disseminated infection in South Africa. N Engl J Med. 2013;369(15):1416–24. doi: 10.1056/NEJMoa1215460 24106934

5. Schwartz IS, Kenyon C, Lehloenya R, Claasens S, Spengane Z, Prozesky H, et al. AIDS-related endemic mycoses in Western Cape, South Africa, and clinical mimics: a cross-sectional study of adults with advanced HIV and recent-onset, widespread skin lesions. Open Forum Infect Dis. 2017;4(4):ofx186. doi: 10.1093/ofid/ofx186 29164168

6. Schwartz IS, Govender NP, Corcoran C, Dlamini S, Prozesky H, Burton R, et al. Clinical characteristics, diagnosis, management and outcomes of disseminated emmonsiosis: a retrospective case series. Clin Infect Dis. 2015;61(6):1004–12. doi: 10.1093/cid/civ439 26060283

7. Maphanga TG, Britz E, Zulu TG, Mpembe RS, Naicker SD, Schwartz IS, et al. In vitro antifungal susceptibility of yeast and mold phases of isolates of dimorphic fungal pathogen Emergomyces africanus (formerly Emmonsia sp.) from HIV-infected South African patients. J Clin Microbiol. 2017;55(6). doi: 10.1128/JCM.02524-16 28356416

8. Jiang Y, Dukik K, Munoz J, Sigler L, Schwartz IS, Govender NP, et al. Phylogeny, ecology and taxonomy of systemic pathogens and their relatives in Ajellomycetaceae (Onygenales): Blastomyces, Emergomyces, Emmonsia, Emmonsiellopsis. Fungal Divers. 2018;90(1):245–91. https://doi.org/10.1007/s13225-018-0403-y.

9. Dukik K, Muñoz JF, Jiang Y, Feng P, Sigler L, Stielow JB, et al. Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales). Mycoses. 2017;60(5):296–309. doi: 10.1111/myc.12601 28176377

10. Pelegrín I, Alastruey-Izquierdo A, Ayats J, Cuenca-Estrella M, Cabellos C. A second look at Emmonsia infection can make the difference. Transpl Infect Dis. 2014;16(3):519–20. doi: 10.1111/tid.12214 24796631

11. Lavergne R-A, Kandel-Aznar C, Khatchatourian L, Garcia-Hermoso D, Jeddi F, Boutoille D, et al. Emmonsia pasteuriana: une cause rare d'infection fongique chez l'immunodéprimé. J Mycol Med. 2017;27(3):e7–e8. doi: 10.1016/j.mycmed.2017.04.025

12. Gast KB, van der Hoeven A, de Boer MGJ, van Esser JWJ, Kuijper EJ, Verweij JJ, et al. Two cases of Emergomyces pasteurianus infection in immunocompromised patients in the Netherlands. Med Mycol Case Rep. 2019. doi: 10.1016/j.mmcr.2019.01.005 30733915

13. Feng P, Yin S, Zhu G, Li M, Wu B, Xie Y, et al. Disseminated infection caused by Emmonsia pasteuriana in a renal transplant recipient. J Dermatol. 2015;42(12):1179–82. doi: 10.1111/1346-8138.12975 26105618

14. Tang XH, Zhou H, Zhang XQ, Han JD, Gao Q. Cutaneous disseminated emmonsiosis due to Emmonsia pasteuriana in a patient with cytomegalovirus enteritis. JAMA Dermatol. 2015;151(11):1263–4. doi: 10.1001/jamadermatol.2015.1792 26200259

15. Malik R, Capoor MR, Vanidassane I, Gogna A, Singh A, Sen B, et al. Disseminated Emmonsia pasteuriana infection in India: a case report and a review. Mycoses. 2016;59(2):127–32. doi: 10.1111/myc.12437 26647904

16. Wilmes D, Rooms I, Heidemarie L, McCormick Smith I, Haase G, Rickerts V. Emergomycosis: Case report of a disseminated Emergomyces pasteurianus infection and review of an emerging fungal infection. 52nd Scientific Conference of the German speaking Mycological Society (DMykG) together with the Austrian Society for Medical Mycology (ÖGMM), 6 September –⁠ 8 September 2018; 6–8 September, 2018; Innsbruck, Austria: Mycoses; 2018.

17. Schwartz IS, Sanche S, Wiederhold NP, Patterson TF, Sigler L. Emergomyces canadensis, a dimorphic fungus causing fatal systemic human disease in North America. Emerg Infect Dis. 2018;24(4). doi: 10.3201/eid2404.171765 29553321

18. Wang P, Kenyon C, de Hoog S, Guo L, Fan H, Liu H, et al. A novel dimorphic pathogen, Emergomyces orientalis (Onygenales), agent of disseminated infection. Mycoses. 2017;60(5):310–9. doi: 10.1111/myc.12583 28240390

19. Wellinghausen N, Kern WV, Haase G, Rozdzinski E, Kern P, Marre R, et al. Chronic granulomatous lung infection caused by the dimorphic fungus Emmonsia sp. Int J Med Microbiol. 2003;293(6):441–5. doi: 10.1078/1438-4221-00281 14760976

20. Schwartz IS, Lerm B, Hoving JC, Kenyon C, Horsnell WG, Basson WJ, et al. Emergomyces africanus in soil, South Africa. Emerg Infect Dis. 2018;24(2). doi: 10.3201/eid2402.171351 29350144

21. Schwartz IS, McLoud JD, Berman D, Botha A, Lerm B, Colebunders R, et al. Molecular detection of airborne Emergomyces africanus, a thermally dimorphic fungal pathogen, in Cape Town, South Africa. PLoS Negl Trop Dis. 2018;12(1). doi: 10.1371/journal.pntd.0006174.

22. Cronjé N, Schwartz IS, Retief L, Bastos ADS, Matthee S, Preiser W, et al. Attempted molecular detection of the thermally dimorphic human fungal pathogen Emergomyces africanus in terrestrial small mammals in South Africa. Med Mycol. 2018;56(4):510–3. doi: 10.1093/mmy/myx065 28992307

23. Schwartz IS, Maphanga TG, Govender NP. Emergomyces: a new genus of dimorphic fungal pathogens causing disseminated disease among immunocompromised persons globally. Curr Fungal Infect Rep. 2018. doi: 10.1007/s12281-018-0308-y

24. Dukik K, Al-Hatmi AMS, Curfs-Breuker I, Faro D, De Hoog S, Meis JF. Antifungal susceptibility of emerging dimorphic pathogens in the family Ajellomycetaceae. Antimicrob Agents Chemother. 2018;62(1):e01886–17. doi: 10.1128/AAC.01886-17 29084748

25. Munoz JF, McEwen JG, Clay OK, Cuomo CA. Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi. Sci Rep. 2018;8(1):4473. Epub 2018/03/16. doi: 10.1038/s41598-018-22816-6 29540755

26. Lerm B, Kenyon C, Schwartz IS, Kroukamp H, de Witt R, Govender NP, et al. First report of urease activity in the novel systemic fungal pathogen Emergomyces africanus: A comparison with the neurotrope Cryptococcus neoformans. FEMS Yeast Research. 2017;17(7). doi: 10.1093/femsyr/fox069 28934415

27. Drouhet E, Huerre M. Yeast tissue phase of Emmonsia pasteuriana inoculated in golden hamster by intratesticular way. Mycoses. 1999;42 Suppl 2 : 11–8. doi: 10.1111/j.1439-0507.1999.tb00006.x 29265616

28. Crombie K, Spengane Z, Locketz M, Dlamini S, Lehloenya R, Wasserman S, et al. Paradoxical worsening of Emergomyces africanus infection in an HIV-infected male on itraconazole and antiretroviral therapy. PLoS Negl Trop Dis. 2018;12(3):e0006173. doi: 10.1371/journal.pntd.0006173 29518092

29. Lochan H, Naicker P, Maphanga T, Ryan A, Pillay K, Govender NP, et al. A case of emmonsiosis in an HIV-infected child. South Afr J HIV Med 2015;16(1). doi: 10.4102/sajhivmed.v16i1.352 29568581

30. Bhagoobhai L, Seetharam S, Wadula J, editors. Dimorphic fungus (Emmonsia species) isolated from sterile sites between March 2014 to April 2015. 6th FIDSSA Congress 2015. Drakensberg, KwaZulu-Natal, South Africa: South Afr J of Infect Dis.