Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys


Autoři: Quintin Lee aff001;  Matthew P. Padula aff002;  Natalia Pinello aff001;  Simon H. Williams aff003;  Matthew B. O'Rourke aff004;  Marcílio Jorge Fumagalli aff005;  Joseph D. Orkin aff006;  Renhua Song aff001;  Babak Shaban aff008;  Ori Brenner aff009;  John E. Pimanda aff010;  Wolfgang Weninger aff001;  William Marciel de Souza aff005;  Amanda D. Melin aff006;  Justin J.-L. Wong aff001;  Marcus J. Crim aff013;  Sébastien Monette aff014;  Ben Roediger aff001;  Christopher J. Jolly aff010
Působiště autorů: Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia aff001;  Proteomics Core Facility, University of Technology Sydney, Sydney, NSW, Australia aff002;  Center for Infection & Immunity, Mailman School of Public Health, Columbia University, New York, NY, United States of America aff003;  Kolling Institute of Medical Research, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia aff004;  Virology Research Center, School of Medicine of Ribeirão Preto of the University of São Paulo, Ribeirão Preto, Brazil aff005;  Institut de Biologia Evolutiva, CSIC-Universitat Pompeu Fabra, Barcelona, Spain aff006;  Department of Anthropology and Archaeology, University of Calgary, Alberta, Canada aff007;  Melbourne Integrative Genomics, University of Melbourne, Melbourne, Victoria, Australia aff008;  Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel aff009;  Lowy Cancer Research Centre, University of New South Wales Sydney, Sydney, NSW, Australia aff010;  Department of Dermatology, Medical University of Vienna, Vienna, Austria aff011;  Department of Medical Genetics and Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Alberta, Canada aff012;  Microbiology and Aquatic Diagnostics, IDEXX BioAnalytics, Discovery Drive, Columbia, MO, United States of America aff013;  Laboratory of Comparative Pathology, Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY, United States of America aff014;  Autoimmunity, Transplantation, Inflammation (ATI) Disease Area, Novartis Institutes for Biomedical Research, Basel, Switzerland aff015
Vyšlo v časopise: Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys. PLoS Pathog 16(1): e32767. doi:10.1371/journal.ppat.1008262
Kategorie: Research Article
doi: 10.1371/journal.ppat.1008262

Souhrn

Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four major MKPV transcripts, created by alternative splicing, to a common initiator region, and use mass spectrometry to identify “p10” and “p15” as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and the splicing-dependent putative accessory protein NS2 are conserved in all near-complete amniote chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with >60% amino acid identity to MKPV. We show that MKPV is kidney-tropic and that the bat chapparvovirus DrPV-1 and a non-human primate chapparvovirus, CKPV, are also found in the kidneys of their hosts. We propose, therefore, that many mammal chapparvoviruses are likely to be nephrotropic.

Klíčová slova:

Bird genomics – Gene prediction – Introns – Kidneys – Mammalian genomics – Parvoviruses – Polymerase chain reaction – Polyadenylation


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