Factors associated with implant survival following total hip replacement surgery: A registry study of data from the National Joint Registry of England, Wales, Northern Ireland and the Isle of Man

Autoři: Jonathan Thomas Evans aff001;  Ashley William Blom aff001;  Andrew John Timperley aff003;  Paul Dieppe aff005;  Matthew James Wilson aff003;  Adrian Sayers aff001;  Michael Richard Whitehouse aff001
Působiště autorů: Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, Bristol, United Kingdom aff001;  National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol, United Kingdom aff002;  Princess Elizabeth Orthopaedic Centre, Royal Devon & Exeter NHS Foundation Trust, United Kingdom aff003;  College of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, United Kingdom aff004;  The University of Exeter Medical School, University of Exeter, Exeter, United Kingdom aff005
Vyšlo v časopise: Factors associated with implant survival following total hip replacement surgery: A registry study of data from the National Joint Registry of England, Wales, Northern Ireland and the Isle of Man. PLoS Med 17(8): e32767. doi:10.1371/journal.pmed.1003291
Kategorie: Research Article
doi: 10.1371/journal.pmed.1003291



Nearly 100,000 people underwent total hip replacement (THR) in the United Kingdom in 2018, and most can expect it to last at least 25 years. However, some THRs fail and require revision surgery, which results in worse outcomes for the patient and is costly to the health service. Variation in the survival of THR implants has been observed between units and reducing this unwarranted variation is one focus of the “Getting it Right First Time” (GIRFT) program in the UK. We aimed to investigate whether the statistically improved implant survival of THRs in a high-performing unit is associated with the implants used or other factors at that unit, such as surgical skill.

Methods and findings

We analyzed a national, mandatory, prospective, cohort study (National Joint Registry for England, Wales, Northern Ireland and the Isle of Man [NJR]) of all THRs performed in England and Wales. We included the 664,761 patients with records in the NJR who have received a stemmed primary THR between 1 April 2003 and 31 December 2017 in one of 461 hospitals, with osteoarthritis as the only indication. The exposure was the unit (hospital) in which the THR was implanted. We compared survival of THRs implanted in the “exemplar” unit with THRs implanted anywhere else in the registry. The outcome was revision surgery of any part of the THR construct for any reason. Net failure was calculated using Kaplan–Meier estimates, and adjusted analyses employed flexible parametric survival analysis.

The mean age of patients contributing to our analyses was 69.9 years (SD 10.1), and 61.1% were female. Crude analyses including all THRs demonstrated better implant survival at the exemplar unit with an all-cause construct failure of 1.7% (95% CI 1.3–2.3) compared with 2.9% (95% CI 2.8–3.0) in the rest of the country after 13.9 years (log-rank test P < 0.001). The same was seen in analyses adjusted for age, sex, and American Society of Anesthesiology (ASA) score (difference in restricted mean survival time 0.12 years [95% CI 0.07–0.16; P < 0.001]). Adjusted analyses restricted to the same implants as the exemplar unit show no demonstrable difference in restricted mean survival time between groups after 13.9 years (P = 0.34).

A limitation is that this study is observational and conclusions regarding causality cannot be inferred. Our outcome is revision surgery, and although important, we recognize it is not the only marker of success of a THR.


Our results suggest that the “better than expected” implant survival results of this exemplar center are associated with implant choice. The survival results may be replicated by adopting key treatment decisions, such as implant selection. These decisions are easier to replicate than technical skills or system factors.

Klíčová slova:

Anesthesiology – Biomaterial implants – England – Surgeons – Surgical and invasive medical procedures – Wales – Total hip replacement – Joint replacement surgery


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PLOS Medicine

2020 Číslo 8
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