Metabolický syndrom – dysregulace endokrinních funkcí tukové tkáně


Autoři: Kateřina Horská;  Jana Kučerová;  Pavel Suchý;  Hana Kotolová
Působiště autorů: Ústav humánní farmakologie a toxikologie FaF, Veterinární a Farmaceutická Univerzita, Brno, ČR
Vyšlo v časopise: Čes. slov. Farm., 2014; 63, 152-159
Kategorie: Přehledy a odborná sdělení

Souhrn

Metabolický syndrom, který výrazně zvyšuje kardiovaskulární morbiditu, mortalitu ariziko rozvoje diabetes mellitus 2. typu, vsoučasné době dosahuje epidemických proporcí. Tato komplexní porucha vyžaduje urgentní vývoj nových farmakoterapeutických řešení. Patofyziologické mechanismy vedoucí k rozvoji tohoto syndromu nejsou dosud plně objasněny, nicméně se zdá zřejmé, že k jeho rozvoji přispívá řada metabolických dysregulací. Za potenciálně slibný cíl pro vývoj nových léčiv se považuje dysregulace endokrinních aparakrinních funkcí tukové tkáně. Specifické adipokiny, což jsou proteiny secernované tukovou tkání s jistými pleiotropními účinky, jsou silně asociovány s regulací energetického metabolismu, chuti k jídlu, inzulinové signální dráhy, senzitivity periferních tkání k inzulinu aprozánětlivému stavu spojenému smetabolickým syndromem. Cílem této práce je poskytnout stručný přehled endokrinních aparakrinních funkcí tukové tkáně ve spojitosti s rozvojem metabolického syndromu, jeho patofyziologických podkladů apoukázat na některé adipokiny jako potenciální cíle pro vývoj nových farmakoterapeutických přístupů.

Klíčová slova:
metabolický syndrominsulinová rezistencetuková tkáňadipokiny


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