Demographic history shaped geographical patterns of deleterious mutation load in a broadly distributed Pacific Salmon

Autoři: Quentin Rougemont aff001;  Jean-Sébastien Moore aff001;  Thibault Leroy aff002;  Eric Normandeau aff001;  Eric B. Rondeau aff004;  Ruth E. Withler aff006;  Donald M. Van Doornik aff007;  Penelope A. Crane aff008;  Kerry A. Naish aff009;  John Carlos Garza aff010;  Terry D. Beacham aff006;  Ben F. Koop aff004;  Louis Bernatchez aff001
Působiště autorů: Département de Biologie, Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec, Québec, Canada aff001;  ISEM, Univ. Montpellier, CNRS, EPHE, IRD, Montpellier, France aff002;  Department of Botany & Biodiversity Research, University of Vienna, Vienna, Austria aff003;  Centre for Biomedical Research, University of Victoria, Victoria, BC, Canada aff004;  Department of Biology, University of Victoria, Victoria, BC, Canada aff005;  Department of Fisheries and Ocean, Pacific Biological Station, Nanaimo, British Columbia, Canada aff006;  National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Northwest Fisheries Science Center, Manchester Research Station, Port Orchard, Washington, United States of America aff007;  Conservation Genetics Laboratory, U.S. Fish and Wildlife Service, Anchorage, Alaska, United States of America aff008;  School of Aquatic and Fishery Sciences, University of Washington, Seattle, WA, United States of America aff009;  Fisheries Ecology Division, Southwest Fisheries Science Center, National Marine Fisheries Service and Institute of Marine Sciences, University of California–Santa Cruz, Santa Cruz, California, United States of America aff010
Vyšlo v časopise: Demographic history shaped geographical patterns of deleterious mutation load in a broadly distributed Pacific Salmon. PLoS Genet 16(8): e32767. doi:10.1371/journal.pgen.1008348
Kategorie: Research Article
doi: 10.1371/journal.pgen.1008348


A thorough reconstruction of historical processes is essential for a comprehensive understanding of the mechanisms shaping patterns of genetic diversity. Indeed, past and current conditions influencing effective population size have important evolutionary implications for the efficacy of selection, increased accumulation of deleterious mutations, and loss of adaptive potential. Here, we gather extensive genome-wide data that represent the extant diversity of the Coho salmon (Oncorhynchus kisutch) to address two objectives. We demonstrate that a single glacial refugium is the source of most of the present-day genetic diversity, with detectable inputs from a putative secondary micro-refugium. We found statistical support for a scenario whereby ancestral populations located south of the ice sheets expanded recently, swamping out most of the diversity from other putative micro-refugia. Demographic inferences revealed that genetic diversity was also affected by linked selection in large parts of the genome. Moreover, we demonstrate that the recent demographic history of this species generated regional differences in the load of deleterious mutations among populations, a finding that mirrors recent results from human populations and provides increased support for models of expansion load. We propose that insights from these historical inferences should be better integrated in conservation planning of wild organisms, which currently focuses largely on neutral genetic diversity and local adaptation, with the role of potentially maladaptive variation being generally ignored.

Klíčová slova:

California – Deletion mutation – Effective population size – Gene flow – Genomics – Phylogeography – Population genetics – Species diversity


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