Trypanosoma brucei infection protects mice against malaria


Autoři: Margarida Sanches-Vaz aff001;  Adriana Temporão aff001;  Rafael Luis aff001;  Helena Nunes-Cabaço aff001;  António M. Mendes aff001;  Sarah Goellner aff001;  Tânia Carvalho aff001;  Luisa M. Figueiredo aff001;  Miguel Prudêncio aff001
Působiště autorů: Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal aff001
Vyšlo v časopise: Trypanosoma brucei infection protects mice against malaria. PLoS Pathog 15(11): e32767. doi:10.1371/journal.ppat.1008145
Kategorie: Research Article
doi: 10.1371/journal.ppat.1008145

Souhrn

Sleeping sickness and malaria are parasitic diseases with overlapping geographical distributions in sub-Saharan Africa. We hypothesized that the immune response elicited by an infection with Trypanosoma brucei, the etiological agent of sleeping sickness, would inhibit a subsequent infection by Plasmodium, the malaria parasite, decreasing the severity of its associated pathology. To investigate this, we established a new co-infection model in which mice were initially infected with T. brucei, followed by administration of P. berghei sporozoites. We observed that a primary infection by T. brucei significantly attenuates a subsequent infection by the malaria parasite, protecting mice from experimental cerebral malaria and prolonging host survival. We further observed that an ongoing T. brucei infection leads to an accumulation of lymphocyte-derived IFN-γ in the liver, limiting the establishment of a subsequent hepatic infection by P. berghei sporozoites. Thus, we identified a novel host-mediated interaction between two parasitic infections, which may be epidemiologically relevant in regions of Trypanosoma/Plasmodium co-endemicity.

Klíčová slova:

Malaria – Malarial parasites – Parasitemia – Parasitic diseases – Plasmodium – Sporozoites – Trypanosoma – Trypanosoma brucei gambiense


Zdroje

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