Distinct genetic variation and heterogeneity of the Iranian population


Autoři: Zohreh Mehrjoo aff001;  Zohreh Fattahi aff001;  Maryam Beheshtian aff001;  Marzieh Mohseni aff001;  Hossein Poustchi aff002;  Fariba Ardalani aff001;  Khadijeh Jalalvand aff001;  Sanaz Arzhangi aff001;  Zahra Mohammadi aff002;  Shahrouz Khoshbakht aff001;  Farid Najafi aff003;  Pooneh Nikuei aff004;  Mohammad Haddadi aff005;  Elham Zohrehvand aff001;  Morteza Oladnabi aff006;  Akbar Mohammadzadeh aff001;  Mandana Hadi Jafari aff001;  Tara Akhtarkhavari aff001;  Ehsan Shamsi Gooshki aff008;  Aliakbar Haghdoost aff010;  Reza Najafipour aff012;  Lisa-Marie Niestroj aff013;  Barbara Helwing aff014;  Yasmina Gossmann aff015;  Mohammad Reza Toliat aff013;  Reza Malekzadeh aff002;  Peter Nürnberg aff013;  Kimia Kahrizi aff001;  Hossein Najmabadi aff001;  Michael Nothnagel aff013
Působiště autorů: Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran aff001;  Digestive Disease Research Centre, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran aff002;  Research Center for Environmental Determinants of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran aff003;  Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran aff004;  Department of Biology, University of Zabol, Zabol, Iran aff005;  Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran aff006;  Department of Medical Genetics, Faculty of Advanced Medical Technologies, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran aff007;  Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran aff008;  Department of Medical Ethics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran aff009;  Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran aff010;  Regional Knowledge Hub, and WHO Collaborating Centre for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran aff011;  Cellular and Molecular Research Centre, Genetic Department, Qazvin University of Medical Sciences, Qazvin, Iran aff012;  Cologne Center for Genomics, University of Cologne, Cologne, Germany aff013;  Department of Archaeology, The University of Sydney, Australia aff014;  Noncommunicable Disease Research Center, Shiraz University of Medical Science, Shiraz, Iran aff015;  University Hospital Cologne, Cologne, Germany aff016
Vyšlo v časopise: Distinct genetic variation and heterogeneity of the Iranian population. PLoS Genet 15(9): e32767. doi:10.1371/journal.pgen.1008385
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pgen.1008385

Souhrn

Iran, despite its size, geographic location and past cultural influence, has largely been a blind spot for human population genetic studies. With only sparse genetic information on the Iranian population available, we pursued its genome-wide and geographic characterization based on 1021 samples from eleven ethnic groups. We show that Iranians, while close to neighboring populations, present distinct genetic variation consistent with long-standing genetic continuity, harbor high heterogeneity and different levels of consanguinity, fall apart into a cluster of similar groups and several admixed ones and have experienced numerous language adoption events in the past. Our findings render Iran an important source for human genetic variation in Western and Central Asia, will guide adequate study sampling and assist the interpretation of putative disease-implicated genetic variation. Given Iran’s internal genetic heterogeneity, future studies will have to consider ethnic affiliations and possible admixture.

Klíčová slova:

Arabic people – Asia – Language – Population genetics – Iran – Paleogenetics – Persian people – Ancient DNA


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