Dynamic localization of SPO11-1 and conformational changes of meiotic axial elements during recombination initiation of maize meiosis


Autoři: Jia-Chi Ku aff001;  Arnaud Ronceret aff002;  Inna Golubovskaya aff002;  Ding Hua Lee aff001;  Chiting Wang aff001;  Ljudmilla Timofejeva aff002;  Yu-Hsin Kao aff001;  Ana Karen Gomez Angoa aff003;  Karl Kremling aff002;  Rosalind Williams-Carrier aff005;  Robert Meeley aff006;  Alice Barkan aff005;  W. Zacheus Cande aff002;  Chung-Ju Rachel Wang aff001
Působiště autorů: Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan aff001;  Department of Molecular and Cell Biology and Plant and Microbial Biology, University of California, Berkeley, CA, United States of America aff002;  Instituto de Biotecnología / UNAM Cuernavaca, Morelos Mexico aff003;  N.I. Vavilov Institute of Plant Industry, St. Petersburg, Russia aff004;  Institute of Molecular Biology, University of Oregon, Eugene, OR, United States of America aff005;  Corteva Agriscience, Johnston, Iowa, United States of America aff006
Vyšlo v časopise: Dynamic localization of SPO11-1 and conformational changes of meiotic axial elements during recombination initiation of maize meiosis. PLoS Genet 16(4): e32767. doi:10.1371/journal.pgen.1007881
Kategorie: Research Article
doi: 10.1371/journal.pgen.1007881

Souhrn

Meiotic double-strand breaks (DSBs) are generated by the evolutionarily conserved SPO11 complex in the context of chromatin loops that are organized along axial elements (AEs) of chromosomes. However, how DSBs are formed with respect to chromosome axes and the SPO11 complex remains unclear in plants. Here, we confirm that DSB and bivalent formation are defective in maize spo11-1 mutants. Super-resolution microscopy demonstrates dynamic localization of SPO11-1 during recombination initiation, with variable numbers of SPO11-1 foci being distributed in nuclei but similar numbers of SPO11-1 foci being found on AEs. Notably, cytological analysis of spo11-1 meiocytes revealed an aberrant AE structure. At leptotene, AEs of wild-type and spo11-1 meiocytes were similarly curly and discontinuous. However, during early zygotene, wild-type AEs become uniform and exhibit shortened axes, whereas the elongated and curly AEs persisted in spo11-1 mutants, suggesting that loss of SPO11-1 compromised AE structural maturation. Our results reveal an interesting relationship between SPO11-1 loading onto AEs and the conformational remodeling of AEs during recombination initiation.

Klíčová slova:

Anthers – Homologous recombination – Chromatin – Chromosome mapping – Chromosome structure and function – Maize – Meiosis – Synapsis


Zdroje

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