1. BrossayL, ChiodaM, BurdinN, KoezukaY, CasoratiG, et al. (1998) CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution. J Exp Med 188: 1521–1528.
2. WunKS, BorgNA, Kjer-NielsenL, BeddoeT, KohR, et al. (2008) A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR. J Exp Med 205: 939–949.
3. CouedelC, PeyratMA, BrossayL, KoezukaY, PorcelliSA, et al. (1998) Diverse CD1d-restricted reactivity patterns of human T cells bearing “invariant” AV24BV11 TCR. Eur J Immunol 28: 4391–4397.
4. KashiwaseK, KikuchiA, AndoY, NicolA, PorcelliSA, et al. (2003) The CD1d natural killer T-cell antigen presentation pathway is highly conserved between humans and rhesus macaques. Immunogenetics 54: 776–781.
5. PorcelliSA, ModlinRL (1999) The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids. Annu Rev Immunol 17: 297–329.
6. MatsudaJL, GapinL, FazilleauN, WarrenK, NaidenkoOV, et al. (2001) Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size. Proc Natl Acad Sci U S A 98: 12636–12641.
7. DianaJ, LehuenA (2009) NKT cells: friend or foe during viral infections? Eur J Immunol 39: 3283–3291.
8. HuT, GimferrerI, Alberola-IlaJ (2011) Control of early stages in invariant natural killer T-cell development. Immunology 134: 1–7.
9. ChunT, PageMJ, GapinL, MatsudaJL, XuH, et al. (2003) CD1d-expressing dendritic cells but not thymic epithelial cells can mediate negative selection of NKT cells. J Exp Med 197: 907–918.
10. PellicciDG, UldrichAP, KyparissoudisK, CroweNY, BrooksAG, et al. (2003) Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramide. Eur J Immunol 33: 1816–1823.
11. GordyLE, BezbradicaJS, FlyakAI, SpencerCT, DunkleA, et al. (2011) IL-15 Regulates Homeostasis and Terminal Maturation of NKT Cells. J Immunol 187: 6335–6345.
12. BezmanNA, ChakrabortyT, BenderT, LanierLL (2011) miR-150 regulates the development of NK and iNKT cells. J Exp Med 208: 2717–2731.
13. ZhengQ, ZhouL, MiQS (2012) MicroRNA miR-150 Is Involved in Valpha14 Invariant NKT Cell Development and Function. J Immunol 188: 2118–2126.
14. BrennanPJ, TatituriRV, BriglM, KimEY, TuliA, et al. (2011) Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals. Nat Immunol 12: 1202–1211.
15. BurrowsPD, KronenbergM, TaniguchiM (2009) NKT cells turn ten. Nat Immunol 10: 669–671.
16. KawakamiK, YamamotoN, KinjoY, MiyagiK, NakasoneC, et al. (2003) Critical role of Valpha14+ natural killer T cells in the innate phase of host protection against Streptococcus pneumoniae infection. Eur J Immunol 33: 3322–3330.
17. KinjoY, IllarionovP, VelaJL, PeiB, GirardiE, et al. (2011) Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol 12: 966–974.
18. MattnerJ, SavagePB, LeungP, OerteltSS, WangV, et al. (2008) Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host Microbe 3: 304–315.
19. KinjoY, TupinE, WuD, FujioM, Garcia-NavarroR, et al. (2006) Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat Immunol 7: 978–986.
20. KumarH, BelperronA, BartholdSW, BockenstedtLK (2000) Cutting edge: CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi. J Immunol 165: 4797–4801.
21. TupinE, BenhniaMR, KinjoY, PatseyR, LenaCJ, et al. (2008) NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi. Proc Natl Acad Sci U S A 105: 19863–19868.
22. BriglM, BrennerMB (2010) How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens. Semin Immunol 22: 79–86.
23. FischerK, ScotetE, NiemeyerM, KoebernickH, ZerrahnJ, et al. (2004) Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells. Proc Natl Acad Sci U S A 101: 10685–10690.
24. KinjoY, WuD, KimG, XingGW, PolesMA, et al. (2005) Recognition of bacterial glycosphingolipids by natural killer T cells. Nature 434: 520–525.
25. WuD, XingGW, PolesMA, HorowitzA, KinjoY, et al. (2005) Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells. Proc Natl Acad Sci U S A 102: 1351–1356.
26. MattnerJ, DebordKL, IsmailN, GoffRD, CantuC3rd, et al. (2005) Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434: 525–529.
27. GrantEP, DeganoM, RosatJP, StengerS, ModlinRL, et al. (1999) Molecular recognition of lipid antigens by T cell receptors. J Exp Med 189: 195–205.
28. MatsudaJL, MallevaeyT, Scott-BrowneJ, GapinL (2008) CD1d-restricted iNKT cells, the ‘Swiss-Army knife’ of the immune system. Curr Opin Immunol 20: 358–368.
29. GodfreyDI, RossjohnJ (2011) New ways to turn on NKT cells. J Exp Med 208: 1121–1125.
30. LeePT, BenlaghaK, TeytonL, BendelacA (2002) Distinct functional lineages of human V(alpha)24 natural killer T cells. J Exp Med 195: 637–641.
31. BendelacA, SavagePB, TeytonL (2007) The biology of NKT cells. Annu Rev Immunol 25: 297–336.
32. KoguchiY, BuenafeAC, ThaulandTJ, GardellJL, Bivins-SmithER, et al. (2012) Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD48 thymocytes and invariant NKT cells but not in Treg cells. PLoS ONE 7: e31296 doi:10.1371/journal.pone.0031296.
33. PeiB, VelaJL, ZajoncD, KronenbergM (2012) Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells. Ann N Y Acad Sci 1253: 68–79.
34. BriglM, BryL, KentSC, GumperzJE, BrennerMB (2003) Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol 4: 1230–1237.
35. PagetC, MallevaeyT, SpeakAO, TorresD, FontaineJ, et al. (2007) Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity 27: 597–609.
36. RafteryMJ, WinauF, GieseT, KaufmannSH, SchaibleUE, et al. (2008) Viral danger signals control CD1d de novo synthesis and NKT cell activation. Eur J Immunol 38: 668–679.
37. BriglM, TatituriRV, WattsGF, BhowruthV, LeadbetterEA, et al. (2011) Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection. J Exp Med 208: 1163–1177.
38. NagarajanNA, KronenbergM (2007) Invariant NKT cells amplify the innate immune response to lipopolysaccharide. J Immunol 178: 2706–2713.
39. WangX, BishopKA, HegdeS, RodenkirchLA, PikeJW, et al. (2012) Human invariant natural killer T cells acquire transient innate responsiveness via histone H4 acetylation induced by weak TCR stimulation. J Exp Med 209: 987–1000.
40. TakahashiT, ChibaS, NiedaM, AzumaT, IshiharaS, et al. (2002) Cutting edge: analysis of human V alpha 24+CD8+ NK T cells activated by alpha-galactosylceramide-pulsed monocyte-derived dendritic cells. J Immunol 168: 3140–3144.
41. IshiharaS, NiedaM, KitayamaJ, OsadaT, YabeT, et al. (1999) CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver. Eur J Immunol 29: 2406–2413.
42. KimCH, ButcherEC, JohnstonB (2002) Distinct subsets of human Valpha24-invariant NKT cells: cytokine responses and chemokine receptor expression. Trends Immunol 23: 516–519.
43. MotsingerA, HaasDW, StanicAK, Van KaerL, JoyceS, et al. (2002) CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection. J Exp Med 195: 869–879.
44. D'AndreaA, GouxD, De LallaC, KoezukaY, MontagnaD, et al. (2000) Neonatal invariant Valpha24+ NKT lymphocytes are activated memory cells. Eur J Immunol 30: 1544–1550.
45. SandbergJK, FastNM, PalaciosEH, FennellyG, DobroszyckiJ, et al. (2002) Selective loss of innate CD4(+) V alpha 24 natural killer T cells in human immunodeficiency virus infection. J Virol 76: 7528–7534.
46. BaevDV, PengXH, SongL, BarnhartJR, CrooksGM, et al. (2004) Distinct homeostatic requirements of CD4+ and CD4− subsets of Valpha24-invariant natural killer T cells in humans. Blood 104: 4150–4156.
47. ChenX, WangX, BesraGS, GumperzJE (2007) Modulation of CD1d-restricted NKT cell responses by CD4. J Leukoc Biol 82: 1455–1465.
48. ThedrezA, de LallaC, AllainS, ZaccagninoL, SidobreS, et al. (2007) CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells. Blood 110: 251–258.
49. TessmerMS, FatimaA, PagetC, TrotteinF, BrossayL (2009) NKT cell immune responses to viral infection. Expert Opin Ther Targets 13: 153–162.
50. ChangYJ, HuangJR, TsaiYC, HungJT, WuD, et al. (2007) Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids. Proc Natl Acad Sci U S A 104: 10299–10304.
51. GumperzJE, MiyakeS, YamamuraT, BrennerMB (2002) Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining. J Exp Med 195: 625–636.
52. TakahashiT, NiedaM, KoezukaY, NicolA, PorcelliSA, et al. (2000) Analysis of human V alpha 24+ CD4+ NKT cells activated by alpha-glycosylceramide-pulsed monocyte-derived dendritic cells. J Immunol 164: 4458–4464.
53. CarnaudC, LeeD, DonnarsO, ParkSH, BeavisA, et al. (1999) Cutting edge: Cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol 163: 4647–4650.
54. La CavaA, Van KaerL, Fu DongS (2006) CD4+CD25+ Tregs and NKT cells: regulators regulating regulators. Trends Immunol 27: 322–327.
55. HuaJ, LiangS, MaX, WebbTJ, PotterJP, et al. (2011) The interaction between regulatory T cells and NKT cells in the liver: a CD1d bridge links innate and adaptive immunity. PLoS ONE 6: e27038 doi:10.1371/journal.pone.0027038.
56. HermansIF, SilkJD, GileadiU, SalioM, MathewB, et al. (2003) NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J Immunol 171: 5140–5147.
57. GalliG, PittoniP, TontiE, MalzoneC, UematsuY, et al. (2007) Invariant NKT cells sustain specific B cell responses and memory. Proc Natl Acad Sci U S A 104: 3984–3989.
58. van der VlietHJ, von BlombergBM, HazenbergMD, NishiN, OttoSA, et al. (2002) Selective decrease in circulating V alpha 24+V beta 11+ NKT cells during HIV type 1 infection. J Immunol 168: 1490–1495.
59. FleuridorR, WilsonB, HouR, LandayA, KesslerH, et al. (2003) CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infection. Immunology 108: 3–9.
60. ChiappiniE, BettiL, BonsignoriF, AzzariC, GalliL, et al. (2010) CD4(+) and CD4(−) CD1D-restricted natural killer T cells in perinatally HIV-1 infected children receiving highly active antiretroviral therapy. Int J Immunopathol Pharmacol 23: 665–669.
61. VasanS, PolesMA, HorowitzA, SiladjiEE, MarkowitzM, et al. (2007) Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection. Int Immunol 19: 943–951.
62. YangOO, WilsonSB, HultinLE, DetelsR, HultinPM, et al. (2007) Delayed reconstitution of CD4+ iNKT cells after effective HIV type 1 therapy. AIDS Res Hum Retroviruses 23: 913–922.
63. MontoyaCJ, CatanoJC, RamirezZ, RugelesMT, WilsonSB, et al. (2008) Invariant NKT cells from HIV-1 or Mycobacterium tuberculosis-infected patients express an activated phenotype. Clin Immunol 127: 1–6.
64. MollM, KuylenstiernaC, GonzalezVD, AnderssonSK, BosnjakL, et al. (2009) Severe functional impairment and elevated PD-1 expression in CD1d-restricted NKT cells retained during chronic HIV-1 infection. Eur J Immunol 39: 902–911.
65. van der VlietHJ, van VonderenMG, MollingJW, BontkesHJ, ReijmM, et al. (2006) Cutting edge: Rapid recovery of NKT cells upon institution of highly active antiretroviral therapy for HIV-1 infection. J Immunol 177: 5775–5778.
66. MollM, Snyder-CappioneJ, SpottsG, HechtFM, SandbergJK, et al. (2006) Expansion of CD1d-restricted NKT cells in patients with primary HIV-1 infection treated with interleukin-2. Blood 107: 3081–3083.
67. LiD, XuXN (2008) NKT cells in HIV-1 infection. Cell Res 18: 817–822.
68. UnutmazD (2003) NKT cells and HIV infection. Microbes Infect 5: 1041–1047.
69. NowickiMJ, VigenC, MackWJ, SeabergE, LandayA, et al. (2008) Association of cells with natural killer (NK) and NKT immunophenotype with incident cancers in HIV-infected women. AIDS Res Hum Retroviruses 24: 163–168.
70. MureithiMW, CohenK, MoodleyR, PooleD, MncubeZ, et al. (2011) Impairment of CD1d-restricted natural killer T cells in chronic HIV type 1 clade C infection. AIDS Res Hum Retroviruses 27: 501–509.
71. GleasonMK, LenvikTR, McCullarV, FelicesM, O'BrienMS, et al. (2012) Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9. Blood 119: 3064–3072.
72. NdhlovuLC, Lopez-VergesS, BarbourJD, JonesRB, JhaAR, et al. (2012) Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood 119: 3734–3743.
73. FernandezCS, ChanAC, KyparissoudisK, De RoseR, GodfreyDI, et al. (2009) Peripheral NKT cells in simian immunodeficiency virus-infected macaques. J Virol 83: 1617–1624.
74. RoutN, ElseJG, YueS, ConnoleM, ExleyMA, et al. (2010) Paucity of CD4+ natural killer T (NKT) lymphocytes in sooty mangabeys is associated with lack of NKT cell depletion after SIV infection. PLoS ONE 5: e9787 doi: 10.1371/journal.pone.0009787.
75. Roelofs-HaarhuisK, WuX, GleichmannE (2004) Oral tolerance to nickel requires CD4+ invariant NKT cells for the infectious spread of tolerance and the induction of specific regulatory T cells. J Immunol 173: 1043–1050.
76. DianaJ, BrezarV, BeaudoinL, DalodM, MellorA, et al. (2011) Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay. J Exp Med 208: 729–745.
77. FavreD, LedererS, KanwarB, MaZM, ProllS, et al. (2009) Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog 5: e1000295 doi:10.1371/journal.ppat.1000295.
78. CohenGB, GandhiRT, DavisDM, MandelboimO, ChenBK, et al. (1999) The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity 10: 661–671.
79. ChenN, McCarthyC, DrakesmithH, LiD, CerundoloV, et al. (2006) HIV-1 down-regulates the expression of CD1d via Nef. Eur J Immunol 36: 278–286.
80. ChoS, KnoxKS, KohliLM, HeJJ, ExleyMA, et al. (2005) Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex. Virology 337: 242–252.
81. AjueborMN (2007) Role of NKT cells in the digestive system. I. Invariant NKT cells and liver diseases: is there strength in numbers? Am J Physiol Gastrointest Liver Physiol 293: G651–656.
82. BendelacA, RiveraMN, ParkSH, RoarkJH (1997) Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu Rev Immunol 15: 535–562.
83. BiburgerM, TiegsG (2005) Alpha-galactosylceramide-induced liver injury in mice is mediated by TNF-alpha but independent of Kupffer cells. J Immunol 175: 1540–1550.
84. ExleyMA, KozielMJ (2004) To be or not to be NKT: natural killer T cells in the liver. Hepatology 40: 1033–1040.
85. KakimiK, GuidottiLG, KoezukaY, ChisariFV (2000) Natural killer T cell activation inhibits hepatitis B virus replication in vivo. J Exp Med 192: 921–930.
86. KakimiK, LaneTE, ChisariFV, GuidottiLG (2001) Cutting edge: Inhibition of hepatitis B virus replication by activated NK T cells does not require inflammatory cell recruitment to the liver. J Immunol 167: 6701–6705.
87. ItoH, AndoK, IshikawaT, NakayamaT, TaniguchiM, et al. (2008) Role of Valpha14+ NKT cells in the development of Hepatitis B virus-specific CTL: activation of Valpha14+ NKT cells promotes the breakage of CTL tolerance. Int Immunol 20: 869–879.
88. WoltmanAM, Ter BorgMJ, BindaRS, SprengersD, von BlombergBM, et al. (2009) Alpha-galactosylceramide in chronic hepatitis B infection: results from a randomized placebo-controlled Phase I/II trial. Antivir Ther 14: 809–818.
89. LiJ, HanY, JinK, WanY, WangS, et al. (2011) Dynamic changes of cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and natural killer T (NKT) cells in patients with acute hepatitis B infection. Virol J 8: 199.
90. TripathyAS, DasR, ChadhaMS, ArankalleVA (2011) Epidemic of Hepatitis B with high mortality in India: association of fulminant disease with lack of CCL4 and natural killer T cells. J Viral Hepat 18: e415–422.
91. LucasM, GadolaS, MeierU, YoungNT, HarcourtG, et al. (2003) Frequency and phenotype of circulating Valpha24/Vbeta11 double-positive natural killer T cells during hepatitis C virus infection. J Virol 77: 2251–2257.
92. DeignanT, CurryMP, DohertyDG, Golden-MasonL, VolkovY, et al. (2002) Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection. J Hepatol 37: 101–108.
93. van der VlietHJ, MollingJW, von BlombergBM, KolgenW, StamAG, et al. (2005) Circulating Valpha24+Vbeta11+ NKT cell numbers and dendritic cell CD1d expression in hepatitis C virus infected patients. Clin Immunol 114: 183–189.
94. InoueM, KantoT, MiyatakeH, ItoseI, MiyazakiM, et al. (2006) Enhanced ability of peripheral invariant natural killer T cells to produce IL-13 in chronic hepatitis C virus infection. J Hepatol 45: 190–196.
95. HarveyCE, PostJJ, PalladinettiP, FreemanAJ, FfrenchRA, et al. (2003) Expression of the chemokine IP-10 (CXCL10) by hepatocytes in chronic hepatitis C virus infection correlates with histological severity and lobular inflammation. J Leukoc Biol 74: 360–369.
96. ApolinarioA, MajanoPL, Alvarez-PerezE, SaezA, LozanoC, et al. (2002) Increased expression of T cell chemokines and their receptors in chronic hepatitis C: relationship with the histological activity of liver disease. Am J Gastroenterol 97: 2861–2870.
97. de LallaC, GalliG, AldrighettiL, RomeoR, MarianiM, et al. (2004) Production of profibrotic cytokines by invariant NKT cells characterizes cirrhosis progression in chronic viral hepatitis. J Immunol 173: 1417–1425.
98. WangH, ParkO, GaoB (2011) NKT cells in liver fibrosis: Controversies or complexities. J Hepatol 55: 1166.
99. IshikawaS, IkejimaK, YamagataH, AoyamaT, KonK, et al. (2011) CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice. J Hepatol 54: 1195–1204.
100. JinZ, SunR, WeiH, GaoX, ChenY, et al. (2011) Accelerated liver fibrosis in hepatitis B virus transgenic mice: involvement of natural killer T cells. Hepatology 53: 219–229.
101. SanchezDJ, GumperzJE, GanemD (2005) Regulation of CD1d expression and function by a herpesvirus infection. J Clin Invest 115: 1369–1378.
102. YuanW, DasguptaA, CresswellP (2006) Herpes simplex virus evades natural killer T cell recognition by suppressing CD1d recycling. Nat Immunol 7: 835–842.
103. RaoP, PhamHT, KulkarniA, YangY, LiuX, et al. (2011) Herpes simplex virus 1 glycoprotein B and US3 collaborate to inhibit CD1d antigen presentation and NKT cell function. J Virol 85: 8093–8104.
104. BosnjakL, SahlstromP, Paquin-ProulxD, LeeansyahE, MollM, et al. (2012) Contact-Dependent Interference with Invariant NKT Cell Activation by Herpes Simplex Virus-Infected Cells. J Immunol 188: 6216–6224.
105. Grubor-BaukB, SimmonsA, MayrhoferG, SpeckPG (2003) Impaired clearance of herpes simplex virus type 1 from mice lacking CD1d or NKT cells expressing the semivariant V alpha 14-J alpha 281 TCR. J Immunol 170: 1430–1434.
106. Grubor-BaukB, ArthurJL, MayrhoferG (2008) Importance of NKT cells in resistance to herpes simplex virus, fate of virus-infected neurons, and level of latency in mice. J Virol 82: 11073–11083.
107. CornishAL, KeatingR, KyparissoudisK, SmythMJ, CarboneFR, et al. (2006) NKT cells are not critical for HSV-1 disease resolution. Immunol Cell Biol 84: 13–19.
108. KulkarniRR, HaeryfarSM, SharifS (2010) The invariant NKT cell subset in anti-viral defenses: a dark horse in anti-influenza immunity? Journal of leukocyte biology 88: 635–643.
109. AshkarAA, RosenthalKL (2003) Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection. J Virol 77: 10168–10171.
110. De SantoC, SalioM, MasriSH, LeeLY, DongT, et al. (2008) Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest 118: 4036–4048.
111. HoLP, DenneyL, LuhnK, TeohD, ClellandC, et al. (2008) Activation of invariant NKT cells enhances the innate immune response and improves the disease course in influenza A virus infection. Eur J Immunol 38: 1913–1922.
112. PagetC, IvanovS, FontaineJ, RennesonJ, BlancF, et al. (2012) Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damage. J Biol Chem 287: 8816–8829.
113. IshikawaH, TanakaK, KutsukakeE, FukuiT, SasakiH, et al. (2010) IFN-gamma production downstream of NKT cell activation in mice infected with influenza virus enhances the cytolytic activities of both NK cells and viral antigen-specific CD8+ T cells. Virology 407: 325–332.
114. BentonKA, MisplonJA, LoCY, BrutkiewiczRR, PrasadSA, et al. (2001) Heterosubtypic immunity to influenza A virus in mice lacking IgA, all Ig, NKT cells, or gamma delta T cells. J Immunol 166: 7437–7445.
115. KokWL, DenneyL, BenamK, ColeS, ClellandC, et al. (2011) Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection. J Leukoc Biol 91: 357–368.
116. ChenWW, XieYX, ZhangYH, FengYQ, LiBA, et al. (2010) [Changes and analysis of peripheral white blood cells and lymphocyte subsets for patients with pandemic influenza A virus (H1N1) infection]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 24: 331–333.
117. KoSY, KoHJ, ChangWS, ParkSH, KweonMN, et al. (2005) alpha-Galactosylceramide can act as a nasal vaccine adjuvant inducing protective immune responses against viral infection and tumor. J Immunol 175: 3309–3317.
118. YounHJ, KoSY, LeeKA, KoHJ, LeeYS, et al. (2007) A single intranasal immunization with inactivated influenza virus and alpha-galactosylceramide induces long-term protective immunity without redirecting antigen to the central nervous system. Vaccine 25: 5189–5198.
119. GuillonneauC, MinternJD, HubertFX, HurtAC, BesraGS, et al. (2009) Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity. Proc Natl Acad Sci U S A 106: 3330–3335.
120. ReillyEC, ThompsonEA, AspeslaghS, WandsJR, ElewautD, et al. (2012) Activated iNKT cells promote memory CD8(+) T cell differentiation during viral infection. PLoS ONE 7: e37991 doi:10.1371/journal.pone.0037991.
121. Kopecky-BrombergSA, FraserKA, PicaN, CarneroE, MoranTM, et al. (2009) Alpha-C-galactosylceramide as an adjuvant for a live attenuated influenza virus vaccine. Vaccine 27: 3766–3774.
122. KamijukuH, NagataY, JiangX, IchinoheT, TashiroT, et al. (2008) Mechanism of NKT cell activation by intranasal coadministration of alpha-galactosylceramide, which can induce cross-protection against influenza viruses. Mucosal Immunol 1: 208–218.
123. LeeYS, LeeKA, LeeJY, KangMH, SongYC, et al. (2011) An alpha-GalCer analogue with branched acyl chain enhances protective immune responses in a nasal influenza vaccine. Vaccine 29: 417–425.
124. CourtneyAN, ThapaP, SinghS, WishahyAM, ZhouD, et al. (2011) Intranasal but not intravenous delivery of the adjuvant alpha-galactosylceramide permits repeated stimulation of natural killer T cells in the lung. Eur J Immunol 41: 3312–3322.
125. WojnoJ, JukesJP, GhadbaneH, ShepherdD, BesraGS, et al. (2012) Amide Analogs of CD1d Agonists Modulate iNKT cell-Mediated Cytokine Production. ACS Chem Biol 7: 847–855.
126. KerzerhoJ, YuED, BarraCM, Alari-PahisaE, GirardiE, et al. (2012) Structural and functional characterization of a novel nonglycosidic type I NKT agonist with immunomodulatory properties. J Immunol 188: 2254–2265.
127. MiuraS, KawanaK, SchustDJ, FujiiT, YokoyamaT, et al. (2010) CD1d, a sentinel molecule bridging innate and adaptive immunity, is downregulated by the human papillomavirus (HPV) E5 protein: a possible mechanism for immune evasion by HPV. J Virol 84: 11614–11623.
128. St JohnAL, RathoreAP, YapH, NgML, MetcalfeDD, et al. (2011) Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance. Proc Natl Acad Sci U S A 108: 9190–9195.
129. RennesonJ, GuabirabaR, MailletI, MarquesRE, IvanovS, et al. (2011) A detrimental role for invariant natural killer T cells in the pathogenesis of experimental dengue virus infection. Am J Pathol 179: 1872–1883.
130. ExleyMA, TahirSM, ChengO, ShaulovA, JoyceR, et al. (2001) A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J Immunol 167: 5531–5534.
131. KronenbergM, GapinL (2002) The unconventional lifestyle of NKT cells. Nat Rev Immunol 2: 557–568.
132. KronenbergM (2005) Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol 23: 877–900.
133. GodfreyDI, StankovicS, BaxterAG (2010) Raising the NKT cell family. Nat Immunol 11: 197–206.
134. MoodyDB, ZajoncDM, WilsonIA (2005) Anatomy of CD1-lipid antigen complexes. Nat Rev Immunol 5: 387–399.
135. BaronJL, GardinerL, NishimuraS, ShinkaiK, LocksleyR, et al. (2002) Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity 16: 583–594.