Exclusive breastfeeding can attenuate body-mass-index increase among genetically susceptible children: A longitudinal study from the ALSPAC cohort

Autoři: Yanyan Wu aff001;  Stephen Lye aff002;  Cindy-Lee Dennis aff003;  Laurent Briollais aff002
Působiště autorů: Office of Public Health Studies, Myron B. Thompson School of Social Work, University of Hawai‘i at Mānoa, Honolulu, Hawai‘i, United States of America aff001;  Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada aff002;  Lawrence S Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada aff003;  Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ontario, Canada aff004;  Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada aff005
Vyšlo v časopise: Exclusive breastfeeding can attenuate body-mass-index increase among genetically susceptible children: A longitudinal study from the ALSPAC cohort. PLoS Genet 16(6): e32767. doi:10.1371/journal.pgen.1008790
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pgen.1008790


Recent discoveries from large-scale genome-wide association studies (GWASs) explain a larger proportion of the genetic variability to BMI and obesity. The genetic risk associated with BMI and obesity can be assessed by an obesity-specific genetic risk score (GRS) constructed from genome-wide significant genetic variants. The aim of our study is to examine whether the duration and exclusivity of breastfeeding can attenuate BMI increase during childhood and adolescence due to genetic risks. A total sample of 5,266 children (2,690 boys and 2,576 girls) from the Avon Longitudinal Study of Parents and Children (ALSPAC) was used for the analysis. We evaluated the role of breastfeeding (exclusivity and duration) in modulating BMI increase attributed to the GRS from birth to 18 years of age. The GRS was composed of 69 variants associated with adult BMI and 25 non-overlapping SNPs associated with pediatric BMI. In the high genetic susceptible group (upper GRS quartile), exclusive breastfeeding (EBF) to 5 months reduces BMI by 1.14 kg/m2 (95% CI, 0.37 to 1.91, p = 0.0037) in 18-year-old boys, which compensates a 3.9-decile GRS increase. In 18-year-old girls, EBF to 5 months decreases BMI by 1.53 kg/m2 (95% CI, 0.76 to 2.29, p<0.0001), which compensates a 7.0-decile GRS increase. EBF acts early in life by delaying the age at adiposity peak and at adiposity rebound. EBF to 3 months or non-exclusive breastfeeding was associated with a significantly diminished impact on reducing BMI growth during childhood. EBF influences early life growth and development and thus may play a critical role in preventing overweight and obesity among children at high-risk due to genetic factors.

Klíčová slova:

Body Mass Index – Breast feeding – Human genetics – Childhood obesity – Children – Obesity – Pediatrics – Pregnancy


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