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Independent validation of experimental results requires timely and unrestricted access to animal models and reagents


Autoři: Cassandra R. Diegel aff001;  Steven Hann aff002;  Ugur M. Ayturk aff002;  Jennifer C. W. Hu aff002;  Kyung-eun Lim aff004;  Casey J. Droscha aff001;  Zachary B. Madaj aff005;  Gabrielle E. Foxa aff001;  Isaac Izaguirre aff001aff006;  Alexander G. Robling aff004;  Matthew L. Warman aff002;  Bart O. Williams aff001
Působiště autorů: Program in Skeletal Disease and Tumor Microenvironment and Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, Michigan, United States of America aff001;  Orthopedic Research Labs, Boston Children’s Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America aff002;  Musculoskeletal Integrity Program, Hospital for Special Surgery Research Institute, New York, New York, United States of America aff003;  Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America aff004;  Bioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, Michigan, United States of America aff005;  Vivarium and Transgenics Core, Van Andel Institute, Grand Rapids, Michigan, United States of America aff006
Vyšlo v časopise: Independent validation of experimental results requires timely and unrestricted access to animal models and reagents. PLoS Genet 16(6): e32767. doi:10.1371/journal.pgen.1008940
Kategorie: Formal Comment
doi: https://doi.org/10.1371/journal.pgen.1008940


Zdroje

1. Diegel CR, Hann S, Ayturk UM, Hu JCW, Lim KE, et al. (2020) An osteocalcin-deficient mouse strain without endocrine abnormalities. PLoS Genet 16: e1008361. doi: 10.1371/journal.pgen.1008361 32463812

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4. Oury F, Sumara G, Sumara O, Ferron M, Chang H, et al. (2011) Endocrine regulation of male fertility by the skeleton. Cell 144: 796–809. doi: 10.1016/j.cell.2011.02.004 21333348

5. Moriishi T, Ozasa R, Ishimoto T, Nakano T, Hasegawa T, et al. (2020) Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass. PLoS Genet 16: e1008586. doi: 10.1371/journal.pgen.1008586 32463816

6. Lambert LJ, Challa AK, Niu A, Zhou L, Tucholski J, et al. (2016) Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology. Dis Model Mech 9: 1169–1179. doi: 10.1242/dmm.025247 27483347

7. Fowlkes JL, Clay Bunn R, Kalaitzoglou E, Ray P, Popescu I, et al. (2020) Postnatal loss of the insulin receptor in osteoprogenitor cells does not impart a metabolic phenotype. Sci Rep 10: 8842. doi: 10.1038/s41598-020-65717-3 32483283

8. von Herrath M, Pagni PP, Grove K, Christoffersson G, Tang-Christensen M, et al. (2019) Case Reports of Pre-clinical Replication Studies in Metabolism and Diabetes. Cell Metab 29: 795–802. doi: 10.1016/j.cmet.2019.02.004 30879984

9. Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, et al. (2008) Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 135: 825–837. doi: 10.1016/j.cell.2008.09.059 19041748

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